连续性肾脏替代治疗在多器官功能障碍综合征中的应用

Application Value of Continuous Renal Replacement Therapy in Multiple Organ Dysfunction Syndrome

目的探讨连续性肾脏替代治疗在多器官功能障碍综合征中的应用价值。方法选取2018年12月至2020年12月洛阳东方医院收治的40例多器官功能障碍综合征患者,根据治疗方法分为对照组和观察组,各20例。对照组接受常规对症治疗,观察组接受连续性肾脏替代治疗,两组均连续治疗2周。比较两组血清肌酐(Scr)、血尿素氮(BUN)、乳酸、C反应蛋白(CRP)、白介素-6(IL-6)、白介素-10(IL-10)以及肿瘤坏死因子-α(TNF-α)水平。结果治疗前两组Scr、BUN、CRP、乳酸、IL-10、IL-6及TNF-α水平相比,差异无统计学意义(P>0.05)。治疗2周后观察组Scr、BUN、CRP及乳酸水平低于对照组(P<0.05)。治疗3 d及2周后,观察组IL-10、IL-6及TNF-α水平低于对照组(P<0.05)。结论连续性肾脏替代治疗对多器官功能障碍综合征疗效较好,可有效清除体内代谢产物及炎症因子,值得临床推广应用。

Objective To explore the application value of continuous renal replacement therapy in multiple organ dysfunction syndrome.Methods A total of 40 patients with multiple organ dysfunction syndrome who were admitted to Luoyang Dongfang Hospital from December 2018 to December 2020 were selected and divided into control group and observation group according to the treatment method,with 20 cases in each group.Control group received conventional symptomatic treatment,and observation group received continuous renal replacement therapy.Both groups received continuous treatment for 2 weeks.The serum creatinine(Scr),blood urea nitrogen(BUN),lactic acid,C-reactive protein(CRP),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels were compared between the two groups.Results There was no statistical difference in the levels of Scr,BUN,CRP,lactic acid,IL-10,IL-6 and TNF-αbetween the two groups before the treatment(P>0.05).After 2 weeks of treatment,the levels of Scr,BUN,CRP and lactic acid in observation group were lower than those in control group(P<0.05).After 3 days and 2 weeks of treatment,the levels of IL-10,IL-6 and TNF-αin observation group were lower than those in control group(P<0.05).Conclusion Continuous renal replacement therapy has a good effect on multiple organ dysfunction syndrome.It could effectively remove metabolites and inflammatory factors from the body and is worthy of clinical application.