血清可溶性髓样细胞触发受体-1水平预测慢性阻塞性肺疾病急性加重期患者预后的价值

Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Predicting Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的分析血清可溶性髓样细胞触发受体-1(sTREM-1)水平预测慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的价值。方法选取2018年9月至2020年9月上蔡县人民医院收治的100例AECOPD患者作为研究对象,进行对症治疗。治疗2周后,根据预后情况分为预后良好组与预后不良组。比较两组血清sTREM-1水平,分析血清sTREM-1与AECOPD患者预后的关系。结果100例患者中,预后良好组62例,占62%,预后不良组38例,占38%。预后不良组血清sTREM-1水平高于预后良好组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,血清sTREM-1水平高表达是AECOPD患者预后不良的危险因素(OR>1,P<0.05)。受试者工作特征曲线(ROC)显示:血清sTREM-1预测AECOPD患者行无创通气治疗预后不良的曲线下面积(AUC)为0.823(>0.7),根据最佳临界值,当血清sTREM-1>121.635μg·L^(-1)时,其灵敏度、特异度较高,为63.2%、90.3%。结论血清sTREM-1高表达可能导致AECOPD患者预后不良,血清sTREM-1水平测定有助于预测AECOPD患者的预后情况,当血清sTREM-1>121.635μg·L^(-1)时,患者预后不良的风险较高。

Objective To analyze the value of soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods The clinical data of 100 AECOPD patients admitted to Shangcai County People’s Hospital from September 2018 to September 2020 were analyzed retrospectively.The symptomatic treatment was carried out.After 2 weeks of treatment,according to the prognosis,they were divided into good prognosis group and poor prognosis group.The serum sTREM-1 levels were compared between the two groups,and the relationship between serum sTREM-1 and prognosis of AECOPD patients was analyzed.Results Of the 100 patients,62 cases(62%)were in good prognosis group,and 38 cases(38%)were in poor prognosis group.The serum sTREM-1 level in the poor prognosis group was higher than that in the good prognosis group(P<0.05).The logistic regression analysis showed that the high expression of serum sTREM-1 was a risk factor of poor prognosis in AECOPD patients(OR>1,P<0.05).The receiver operating characteristic curve(ROC)showed that the area under curve(AUC)of serum sTREM-1 in predicted poor prognosis of noninvasive ventilation therapy in patients with AECOPD was 0.823(>0.7).According to the best critical value,when the serum sTREM-1 was>121.635μg·L^(-1),its sensitivity and specificity were higher,which were 63.2%and 90.3%respectively.Conclusion The high expression of serum sTREM-1 may lead to poor prognosis in AECOPD patients,and the serum sTREM-1 level is helpful to predict the prognosis of AECOPD patients.When serum sTREM-1 is>121.635μg·L^(-1),the risk of poor prognosis is higher.