C反应蛋白、降钙素原及铁蛋白水平在急性胰腺炎患者中的变化及意义

Changes and significance of C reactive protein,procalcitonin and ferritin levels in patients with acute pancreatitis

目的分析C反应蛋白(CRP)、降钙素原(PCT)及铁蛋白(SF)在急性胰腺炎(AP)患者中的变化及意义。方法选取2018年5月至2020年5月该院收治的急性胰腺炎患者105例,其中轻症急性胰腺炎(MAP)68例作为MAP组,重症急性胰腺炎(SAP)37例作为SAP组,分别检测患者入院第1、3、5、7天的CRP、PCT及SF水平,并选取50例体检健康者作为对照组。对3组的CRP、PCT及SF水平进行比较。结果SAP组和MAP组CRP、PCT及SF水平均高于对照组,差异有统计学意义(P<0.05)。SAP组患者入院第3、5、7天CRP水平均高于MAP组(P<0.05),第1、3、5、7天PCT及SF水平均高于MAP组(P<0.05)。结论血清CRP、PCT及SF水平与AP的发生、发展相关,动态检测3项指标可评估AP的严重程度。

Objective To analyze the changes and significance of C reactive protein(CRP),procalcitonin(PCT)and ferritin(SF)in patients with acute pancreatitis(AP).Methods A total of 105 patients with acute pancreatitis admitted to our hospital from May 2018 to May 2020 were enrolled in the study,including 68 patients with mild acute pancreatitis(MAP)as the MAP group and 37 patients with severe acute pancreatitis(SAP)as the SAP group.CRP,PCT and SF levels of patients were detected on the 1st day,3rd day,5th day,and 7th day in hospital.Fifty healthy people who had undergone healthy examination were enrolled as the control group.CRP,PCT and SF levels were tested and compared among the three groups.Results The CRP,PCT and SF levels in the SAP group and the MAP group were higher than those in the control group(P<0.05).The levels of CRP in the SAP group were higher than those in the MAP group on the 3rd,5th and 7th day in hospital(P<0.05),and the levels of PCT and SF were higher than those in the MAP group on the 1st,3rd,5th and 7th day in hospital(P<0.05).Conclusion Serum CRP,PCT and SF levels are related to the occurrence and development of AP,and dynamic detection of the 3 indicators can assess the severity of AP.