基于数据挖掘探究治疗动脉粥样硬化的组方规律

Research on the Prescription Rules for the Treatment of Atherosclerosis Based on Data Mining

目的:分析中国期刊全文数据库(CNKI)治疗动脉粥样硬化专利及用药规律,为中医经验的传承与发展奠定基础。方法:通过检索《中国知网专利数据库》关于治疗动脉粥样硬化的中药专利,利用Excel 2010和中医传承辅助系统(V2.50)对申请专利年份、地区、药物及其类别、关联度进行系统处理,并对结果进行有效分析。结果:共收集到370个专利,涉及药物780味,累计引用3809频次;频次排名前5位的药物类别为补虚药(683)、活血化瘀药(610)、清热药(221)、解表药(220)、利水渗湿药(169);使用频次(f)≥30的中药有23味,频次排名前5位的药物为丹参、山楂、黄芪、川芎、三七;药性以温热居多,5味主要以甘、苦、辛为主,归经以归肝、脾、心经居多;频次≥25的药物组合有21个,包含15味药物,所得新处方12个。结论:我国动脉粥样硬化防治状况十分严峻,但防治动脉粥样硬化中药的专利数量近几年有下降趋势,需要加强对动脉粥样硬化疾病的重视。对治疗动脉粥样硬化中药专利进行系统分析,得到候选新方12个,为临床治疗动脉粥样硬化用药提供参考。

Objective:To use the Traditional Chinese Medicine Inheritance Support System(TCMISS)(V2.5),the patents of atherosclerosis in the China National Knowledge Infrastructure(CNKI)are analyzed to lay a foundation for the inheritance and development of the experience of traditional Chinese medicine.Methods:In this paper,the author searched anti-atherosclerosis patents on traditional Chinese medicine in the CNKI.This article uses Excel 2010 and the TCMISS(V2.50)to systematically process by the way of the year,region,medicine,category and degree of relevance of the patents application and analyze the results effectively.Results:In this paper,a total of 370 patents involving 780 flavors of drugs were collected,with a cumulative frequency of 3809.The top five drug categories are tonic deficiency drugs(683),activating blood circulation and removing blood stasis drugs(610),heat-clearing drugs(221),relieving superficies medicines(220)and diuretic medicine(169).Chinese medicines with frequency(f)≥30 have 23 flavors,which of The top five medicines are Salvia miltiorrhiza Bge.,Crataegus pinnatifida Bunge,stragalus membranaceus(Fisch.)Bunge.,ligusticum chuanxiong hort.,Panax notoginseng..The medicinal properties are mostly warm.The frequency of five flavors is frequent the order is sweet,bitter,and spicy and most of channel tropism are liver,spleen and heart.Conclusion:In China,the condition of atherosclerosis is very serious,but the number of patents for atherosclerosis in traditional Chinese medicines has been declining in recent years.We need to pay more attention to atherosclerosis.The author systematically analyzed the patents of traditional Chinese medicines for the treatment of atherosclerosis and obtained 12 new prescriptions,which provides references for the clinical treatment of atherosclerosis.