继发性铁过载一例分析及药学监护

Case analysis and pharmaceutical care of secondary iron overload

铁过载分为原发性和继发性,继发性铁过载常见于反复输血、长期应用静脉铁剂的患者中。在血液透析患者中,静脉铁剂引起的继发性铁过载风险大。本文报告1例北京友谊医院收治的术后输血(2000 mL)输铁(18100 mg)发生继发性铁过载的病例。铁过载会造成肝脏、心脏等靶器官损害,对于继发性铁过载高风险人群应密切监测铁代谢的血浆标志物和肝脏铁储存量,减少铁过载的发生。

Iron overload syndromes may be genetic or acquired.Repeated transfusion therapy and chronic use of intrave⁃nous iron products usually lead to secondary iron overload.This paper reported a case of secondary iron overload after repeated transfusion therapy(2000 mL)and chronic use of intravenous iron products(18100 mg)in Beijing Friendship Hospital.Iron overload can cause damage to liver,heart and other target organs.For high-risk patients,closely monitor on the iron metabo⁃lism markers and liver iron storage should be taken to reduce secondary iron overload.