动脉粥样硬化斑块磁共振成像动物模型

Animal Models for Magnetic Resonance Imaging of Atherosclerotic Plaque

动脉粥样硬化是严重威胁人体健康的心血管疾病,通过建立粥样硬化斑块动物模型,研究探索动脉粥样硬化的病理生理变化,对临床诊疗有重要价值。磁共振成像可无创评价全身大动脉粥样硬化斑块,是评价动脉粥样硬化斑块形态、成份及稳定性的有效影像技术。现将有关兔、猪及鼠动脉粥样硬化斑块动物模型的构建及磁共振成像进行综述,归纳总结不同方法的优势和劣势,为以后研究提供参考。

Atherosclerosis is a cardiovascular disease which seriously threatens public health.Understanding the pathophysiology of atherosclerosis by establishment of atherosclerotic plaque animal models is of great value for clinical diagnosis and treatment.Magnetic resonance imaging(MRI)enables non-invasively assessing the morphology,composition and stability of atherosclerotic plaques.The construction and MRI of animal models of atherosclerotic plaques in rabbits,pigs and mice were reviewed.The advantages and disadvantages of different methods are summarized to provide references for future studies.