达比加群酯治疗PCI术后患者房颤的疗效

Efficacy of dabigatran etexilate in the treatment of patients with coronary heart disease and atrial fibrillation after PCI

目的探究达比加群酯治疗冠心病(CHD)合并房颤行经皮冠状动脉介入术(PCI)术后患者的效果及其对凝血功能、血液流变学指标的影响。方法选取我科2018年6月至2020年8月期间107例CHD合并房颤行PCI患者作为研究对象,对照组53例术后口服阿司匹林、氯吡格雷治疗,观察组54例在上述治疗基础上加用达比加群酯胶囊治疗,观察两组患者的临床疗效,凝血功能,血液流变学指标,出血事件及血栓栓塞事件。结果治疗后,对照组总有效率较观察组低(p<0.05);凝血功能较观察组低(p<0.05);血液流变学指标均较观察组高(p<0.05);出血及血栓栓塞事件高于观察组(p<0.05)。结论达比加群酯应用于PCI术后患者可有效改善凝血功能,恢复血液流变学,提高临床疗效,且安全性较高。

Objective To explore the effect of Dabigatran Etexilate in the treatment of patients with coronary heart disease(CHD)combined with atrial fibrillation undergoing percutaneous coronary intervention(PCI)and its influence on coagulation function and hemorheological indexes.Methods From June 2018 to August 2020 in our department,107 patients with CHD and atrial fibrillation who underwent PCI were selected as the research objects.The control group 53 patients were treated with aspirin and clopidogrel after operation,and 54 patients in the observation group were based on the above treatment.Add dabigatran etexilate capsules to observe the clinical efficacy,coagulation function,hemorheology indexes,bleeding events and thromboembolic events of the two groups of patients.Results After treatment,the total effective rate of the control group was lower than that of the observation group(p<0.05);the coagulation function was lower than that of the observation group(p<0.05);the hemorheology indexes were higher than those of the observation group(p<0.05);bleeding and thrombosis The embolism event was higher than the observation group(p<0.05).Conclusions Dabigatran Etexilate applied to patients after PCI can effectively improve blood coagulation function,restore hemorheology,improve clinical efficacy,and has high safety.