温阳健脾方联合西医常规疗法治疗乙型肝炎肝硬化失代偿期患者的研究

Application of Wenyang Jianpi prescription combined with western medicine routine therapy in the treatment of decompensated hepatitis B cirrhosis

目的:探讨温阳健脾方联合西医常规疗法治疗乙型肝炎肝硬化失代偿期患者的应用效果。方法:选取2018年1月至2019年12月收治的乙型肝炎肝硬化失代偿期患者106例,应用数字列表法将其随机分为两组,对照组患者采用西医常规疗法治疗,研究组患者采用温阳健脾方联合西医常规疗法治疗。比较两组患者临床疗效、中医证候积分、白蛋白(Alb)、总胆红素(TBil)、谷草转氨酶(AST)、谷丙转氨酶(ALT)水平、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(C-Ⅳ)、血清透明质酸(HA)等纤维化指标情况。结果:研究组临床疗效高于对照组(P<0.05);研究组患者下肢水肿、神疲怯寒、脘闷纳呆、腹部胀满等中医证候积分小于对照组(P<0.05);研究组患者Alb水平高于对照组(P<0.05),研究组患者TBil、AST、ALT、PC-Ⅲ、C-Ⅳ、HA水平低于对照组(P<0.05)。结论:温阳健脾方联合西医常规疗法治疗乙型肝炎肝硬化失代偿期的临床疗效较高,值得临床应用。

Objective:To investigate the efficacy of Wenyang Jianpi prescription combined with western medicine in the treatment of decompensated hepatitis b cirrhosis.Methods:A total of 106 patients with decompensated hepatitis B cirrhosis admitted to our hospital from January 2018 to December 2019 were randomly divided into two groups by random number table method.Compare two groups of patients with clinical efficacy,lower extremity edema,exhausted god afraid cold,stomach,the often boring stay,such as traditional Chinese medicine symptom integral,albumin(propagated),total bilirubin(TBil),aspertate aminotransferase(AST),alanine aminotransferase(ALT)levels,Ⅲbefore collagen(PC-Ⅲ),collagen typeⅣ(C-Ⅳ),serum hyaluronic acid(HA),fibrosis indexes such as.Results:The clinical efficacy of the study group was higher than that of the control group(P<0.05).In the study group,the scores of symptoms of lower limb edema,mental fatigue,chills,astringency and abdominal fullness were lower than those of the control group(P<0.05).Alb levels in the study group were higher than those in the control group(P<0.05),while TBil,AST and ALT levels in the study group were lower than those in the control group(P<0.05).The team PC-Ⅲ,C-Ⅳ,HA level is lower than the control group(P<0.05).Conclusion:In the treatment of decompensated hepatitis b cirrhosis,wenyang jianpi prescription combined with western medicine routine therapy has a high clinical efficacy and is worthy of clinical use.