硝苯地平联合硫酸镁治疗子痫前期的疗效及对分娩结局的影响

Efficacy of nifedipine combined with magnesium sulfate in the treatment of preeclampsia and its influence on the outcome of childbirth

目的观察硝苯地平联合硫酸镁治疗子痫前期的疗效及对分娩结局的影响。方法选取2018年1月-2019年12月广东省吴川市妇幼保健计划生育服务中心收治的子痫前期患者70例,依据随机数字表法分为观察组及对照组各35例。对照组给予硫酸镁治疗,观察组给予硝苯地平联合硫酸镁治疗。比较2组患者临床疗效、治疗前后血压(收缩压、舒张压)、尿蛋白水平、血流动力学指标[红细胞压积、血液黏度、脐动脉舒张压血流峰速比值(S/D)、阻力指数(RI)]及分娩不良结局。结果观察组患者总有效率为94.29%,高于对照组的77.14%(χ^(2)=4.200,P=0.040);治疗3 d后,2组患者收缩压、舒张压、尿蛋白水平、红细胞压积、血液黏度、S/D、RI均低于治疗前,且观察组低于对照组(P<0.01);观察组患者分娩不良结局总发生率为5.71%,低于对照组的22.86%(χ^(2)=4.200,P=0.040)。结论硝苯地平联合硫酸镁治疗子痫前期可有效改善患者症状及分娩结局,值得推广应用。

Objective To observe the efficacy of nifedipine combined with magnesium sulfate in the treatment of preeclampsia and its influence on the outcome of childbirth.Methods From January 2018 to December 2019,70 patients with preeclampsia admitted to the Wuchuan Maternal and Child Health Family Planning Service Center in Guangdong Province were selected and divided into observation group and control group with 35 cases each according to the random number table method.The control group was given magnesium sulfate treatment,and the observation group was given nifedipine combined with magnesium sulfate treatment.Compared the clinical efficacy,blood pressure(systolic blood pressure,diastolic blood pressure),urinary protein level,hemodynamic indicators[hematocrit,blood viscosity,umbilical artery diastolic blood flow peak velocity ratio(S/D),resistance index(RI)]before and after treatment and delivery outcomes between the two groups.Results The total effective rate of patients in the observation group was 94.29%,which was higher than 77.14%in the control group(χ^(2)=4.200,P=0.040);After 3 days of treatment,the systolic blood pressure,diastolic blood pressure,urine protein level,hematocrit,blood viscosity,S/D and RI of the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.01);The overall incidence of adverse delivery outcomes in the observation group was5.71%,which was lower than 22.86%in the control group(χ^(2)=4.200,P=0.040).Conclusion Nifedipine combined with magnesium sulfate in the treatment of preeclampsia can effectively improve the symptoms and delivery outcomes of patients,and it is worthy of popularization and application.