氨溴特罗口服溶液联合阿奇霉素干混悬剂辅助治疗小儿支原体肺炎的效果

Effect of ambroxol oral solution combined with azithromycin dry suspension in adjuvant treatment of mycoplasma pneumonia in children

目的观察氨溴特罗口服溶液联合阿奇霉素干混悬剂辅助治疗小儿支原体肺炎的效果。方法回顾性选取2019年10月-2020年4月四川省广元市中心医院普儿一科收治的支原体肺炎住院患儿88例,根据治疗方法不同分为观察组43例和对照组45例。2组均采用常规治疗,对照组在常规治疗的基础上应用阿奇霉素干混悬剂治疗,观察组在对照组治疗的基础上应用氨溴特罗口服溶液治疗。比较2组患儿临床疗效,治疗前、治疗3 d、5 d、7 d发热、肺部湿啰音、咳嗽、咯痰症状及住院时间单项评分、综合评分、不良反应。结果治疗3周后,观察组患儿总有效率为93.02%,高于对照组的60.00%,差异有统计学意义(χ^(2)=13.198,P=0.000)。治疗3 d、5 d、7 d后,2组患儿发热、肺部湿啰音、咳嗽、咯痰及综合评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗5 d、7 d后,2组患儿住院时间评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.01)。2组患儿不良反应总发生率比较差异无统计学意义(χ^(2)=0.002,P=0.963)。结论氨溴特罗口服溶液联合阿奇霉素干混悬剂辅助治疗小儿支原体肺炎疗程更短、疗效更好,值得临床推广。

Objective To observe the effect of ambroxol oral solution combined with azithromycin dry suspension in adjuvant treatment of mycoplasma pneumonia in children.Methods A retrospective selection of 88 hospitalized children with mycoplasma pneumonia admitted to the General Pediatric Department of Guangyuan Central Hospital,Sichuan Province from October 2019 to April 2020,they were divided into observation group(43 cases)and control group(45 cases)according to different treatment methods.Both groups were treated with conventional treatment,the control group was treated with azithromycin dry suspension on the basis of conventional treatment,and the observation group was treated with ambroxol oral solution on the basis of the treatment of the control group.The clinical efficacy,the scores of fever,pulmonary rales,cough,sputum symptoms,individual scores at pre-treatment,3 days,5 days,and 7 days of treatment,comprehensive scores and adverse reactions were compared between the two groups.Results After 3 weeks of treatment,the total effective rate of children in the observation group was 93.02%,which was higher than 60.00%in the control group,the difference was statistically significant(χ^(2)=13.198,P=0.000).After 3 days,5 days,7 days of treatment,the scores of fever,pulmonary rales,cough,sputum and comprehensive in the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05);After 5 days and 7 days of treatment,the score of hospitalization time in the two groups were lower than before treatment,and the observation group was lower than that of the control group,the differences were statistically significant(P<0.01).There was no significant difference in the total incidence of adverse reactions between the two groups of children(χ^(2)=0.002,P=0.963).Conclusion Ambroxol oral solution combined with azithromycin dry suspension for adjuvant treatment of mycoplasma pneumonia in children has a shorter course and better curative effect,which is worthy of clinical promotion.