Self-renewal of peripheral nerve resident macrophage:does it represent a unique activation status?

Macrophages are immune cells of myeloid origin and are present in almost all tissues.They perform a wide variety of functions contributing to tissue development,homeostasis,pathogenesis,and repair(Wynn et al.,2013).Strikingly,macrophages residing at different tissues,and at different compartments of an individual tissue,demonstrate enormously diverse molecular characteristics(Gordon and Taylor,2005).