大麻二酚抗阿尔茨海默病活性研究进展

Progress of Research on Anti-Alzheimer’s Disease Activity of Cannabidiol

阿尔茨海默病是以认知能力下降为特征的常见的神经退行性疾病,临床表现为记忆障碍、语言障碍和认知障碍等,主要由淀粉样蛋白β沉积和tau蛋白过度磷酸化引起。大麻二酚是大麻中特有的萜类次生代谢产物,无神经依赖性,具有神经保护、抗氧化和抗炎特性,且在体内有效,近年来已成为阿尔茨海默病治疗领域的研究热点。总结了大麻二酚在体内外阿尔茨海默病模型中的生物活性研究进展,为相关新药的研发提供思路与参考。

Alzheimer’s disease(AD)is a common neurodegenerative disease characterized by cognitive decline.The clinical impairment of memory,language and cognitive ability is mainly caused byβ-amyloid(Aβ)deposition and hyperphosphorylation of tau.Cannabidiol(CBD),a specific terpenoid secondary metabolite in cannabis,does not produce neurodependence.It has neuroprotective,antioxidant and anti-inflammatory properties,and is also effective in vivo.In recent years,CBD has become a research hotspot for the treatment of AD.This article summarizes the research progress of CBD activities in AD models in vitro and in vivo,so as to provide reference and thought for future research on related new drugs.