新型长效抗菌缓释敷料的制备及性能

Preparation and Property of Controlled-Release Novel Dressing with Long Antibacterial Role

采用溶液共混法制得了姜黄素-聚己内酯/聚乳酸(CUR-PCL/PLA)药物薄膜,通过傅里叶变换红外光谱仪(FTIR)、扫描电子显微镜(SEM)对药物薄膜结构和形态进行了表征,考察了药物薄膜的包封率、缓释性和降解性的影响因素。结果表明:CUR质量浓度为0.010 g/mL,PCL和PLA总质量浓度为0.050 g/mL,PLA/PCL质量比为2∶1时,药物薄膜的包封率达到28.43%,在磷酸盐(PBS)缓冲液中,80 h的CUR累计释放率达到80%以上,表明该药物薄膜具有明显的药物缓释作用。

Curcumin-polycaprolactone/polylactic acid(CUR-PCL/PLA)drug films were prepared by solution-blending method.The structure and morphology were observed by FTIR and SEM.The encapsulation efficiency,controlled release properties and degradation properties of drug films were investigated.The results show that when the concentration of CUR is 0.010 g/mL,and the total concentration of PCL and PLA is 0.050 g/mL,and the mass ratio of PLA/PCL is 2∶1,the drug loading of samples reaches 28.43%and the cumulative release rate of CUR reaches more than 80%at 80 h in PBS buffer solution.