生殖支原体耐药现状及机制

Advances in antibiotic resistance and mechanism of Mycoplasma genitalium

生殖支原体对四环素类、大环内酯类、氟喹诺酮类药物均已出现耐药,且耐药率逐年增加,甚至出现了多重耐药的现象。大环内酯类药物的耐药主要由23S rRNA单碱基突变所致,氟喹诺酮类耐药与parC、gyrA、gyrB、parE突变相关,四环素类药物的耐药机制尚不明确。生殖支原体耐药发展迅速,如何控制其发展及寻找新药物治疗已成为全球亟待解决的问题。此文就生殖支原体耐药机制及其耐药现状进行综述,为临床治疗提供参考。

Mycoplasma genitalium has been resistant to tetracyclines,macrolides and fluoroquinolones.The drug resistance rate has increased year by year,and even multi-drug resistance has appeared.Macrolide resistance is mainly caused by 23S rRNA single base mutation,fluoroquinolone resistance is related to parC.gyrA,gyrB,parE mutation,and tetracycline resistance is unclear.With the rapid development of drug resistance of Mycoplasma genitalium,how to control its development and find new drugs has become a global problem to be solved urgently.The mechanism and general situation of drug resistance of Mycoplasma genitalium are reviewed in order to provide a reference for clinical understanding of drug resistance status of Mycoplasma genitalium.