间充质干细胞囊泡治疗支气管肺发育不良的动物实验研究进展

Advances on animal experimental study of mesenchymal stem cell extracellular vesicles in the treatment of bronchopulmonary dysplasia

支气管肺发育不良(BPD)是一种常见于需要机械通气和氧疗的早产儿慢性肺部疾病。BPD通常长期预后差,目前尚无有效的预防和治疗方法,是亟待解决的医学难题之一。基于许多动物实验结果证实,间充质干细胞细胞外囊泡(MSC-EVs)可替代间充质干细胞作为BPD的有效治疗策略,具有很大的应用前景。目前对MSC-EVs治疗作用的研究逐渐深入到分子机制,并已取得成果。现对近年来在MSC-EVs治疗BPD的作用机制方面取得的进展进行综述,以探讨MSC-EVs治疗BPD的价值。

Bronchopulmonary dysplasia(BPD)is a chronic lung disease that commonly occurs in preterm infants requiring mechanical ventilation and oxygen therapy.BPD usually has a poor long-term prognosis due to the lack of effective prevention and treatment method currently,which is one of the medical problems to be solved urgently.Many animal experiments indicated that mesenchymal stem cell extracellular vesicles(MSC-EVs)can replace mesenchymal stem cells as an effective treatment strategy for BPD,which has great application prospect.At present,the use of MSC-EVs has gradually deepened into the molecular mechanism and made new progress.In order to explore the value of MSC-EVs in the treatment of BPD,the recent advances on the mechanism of MSC-EVs in the treatment of BPD are investigated.