七子补肾育卵方治疗早发性卵巢功能不全50例临床研究

Qizi Bushen Yuluan Formula for primary ovarian insufficiency:50 cases clinical studies

目的观察七子补肾育卵方治疗早发性卵巢功能不全(POI)的临床疗效。方法将80例POI患者根据患者意愿分为2组,对照组30例采用激素补充治疗(HRT),治疗组50例予七子补肾育卵方治疗。比较2组临床疗效和治疗前后卵泡刺激素(FSH)、雌二醇(E_(2))、抗苗勒管激素(AMH)水平及双侧窦卵泡数(AFC),双侧卵巢体积、卵巢动脉阻力指数(RI)平均值,子宫内膜厚度、中医证候评分变化。结果治疗组总有效率94.0%(47/50),对照组总有效率66.7%(20/30),治疗组总有效率高于对照组(P<0.5)。治疗后2组FSH水平均较本组治疗前降低,E_(2)和AMH水平升高(P<0.05),且治疗组FSH水平低于对照组(P<0.05),E_(2)和AMH水平均高于对照组(P<0.05)。治疗后2组AFC及子宫内膜厚度均较本组治疗前增加,卵巢体积增大,RI降低(P<0.05),且治疗组各指标改善均优于对照组(P<0.05)。治疗后2组各中医证候评分及总分均低于本组治疗前(P<0.05),且治疗组均低于对照组(P<0.05)。结论七子补肾育卵方治疗POI临床疗效确切,能有效调节患者激素水平,改善卵巢功能。

ObjectiveTo observe the clinical efficacy of Qizi Bushen Yuluan Formula for primary ovarian insufficiency(POI).MethodsTotally 80 POI patients were assigned into two groups from the wishes of patients,30 cases in control group were treated with hormone replacement therapy(HRT),and 50 cases in treatment group were treated with Qizi Bushen Yuluan Formula.The key observation was clinical efficacy,follicle stimulating hormone(FSH),estradiol(E_(2)),anti-mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,ovarian artery resistance index(RI),and traditional Chinese medicine(TCM)syndrome score between groups before and after treatment.ResultsThe total effective rates were better in treatment group than in control group[94.0%(47/50)vs 66.7%(20/30),(P<0.05),respectively].Compared with before treatment,FSH in both groups was lower after treatment(P<0.05),which in treatment group was significantly decreased(P<0.05);while E_(2) and AMH in groups were higher(P<0.05),which in treatment group were significantly increased(P<0.05);AFC and endometrial thickness in groups were higher after treatment,while ovarian volume and RI were lower(P<0.05),and various indicators was better in treatment group than in control group(P<0.05);TCM syndrome score and total scores in groups were lower after treatment(P<0.05),which in treatment group were significantly decreased(P<0.05).ConclusionFor POI patients,Qizi Bushen Yuluan Formula has a definite clinical effect,can effectively regulate hormone levels,and improve ovarian function.