芡欧鼠尾草中1个新的二萜化合物

A new diterpenoid from Salvia hispanica

目的研究芡欧鼠尾草Salvia hispanica地上部分的化学成分。方法采用硅胶、Sephadex LH-20、HPLC等各种现代色谱分离技术进行系统地分离纯化,根据波谱数据结合改良的Mosher法对化合物进行结构鉴定。结果从芡欧鼠尾草地上部分的丙酮提取物中分离得到了3个化合物,分别鉴定为(5S,7R,9R,10R,12R)-二羟基-8,17-二去氢车桑子内酯(1)、12-hydroxyhardwickic acid(2)和14-triene-17,12R:18,19-diolide(3)。结论化合物1为新二萜化合物,命名为芡欧鼠尾内酯A,化合物3为首次报道从该植物中分离得到。

Objective To study the chemical constituents of the aerial parts of Salvia hispanica.Methods The compounds were isolated and purified by various modern chromatographies,and their structures were identified by spectroscopic data and modified Mosher’s method.Results Three compounds were isolated from the acetone extract of the aerial parts of S.hispanica,which were elucidated as(5 S,7 R,9 R,10 R,12 R)-dihydroxy-8,17-didehydrohautriwaic lactone(1),12-hydroxyhardwickic acid(2)and 14-triene-17,12 R:18,19-diolide(3).Conclusion Compound 1 is a new diterpenoid,named hispanlactone A,and compound 3 is isolated from this plant for the first time.