特发性肺纤维化相关的免疫评估及动态监测标志物

Molecular markers for immunological evaluation and monitoring of patients with idiopathic pulmonary fibrosis

特发性肺纤维化(IPF)是常见的病因不明的肺间质疾病,发病机制不明,尚无特效药物,其进展缓急、病情预后呈异质性。多项研究发现机体及肺部免疫系统功能异常可能与1PF发病、进展及预后相关,本文结合文献综合分析了IPF相关多种免疫细胞及细胞因子、免疫球蛋白在IPF患者外周血和支气管肺泡灌洗液的分布情况,探讨这些作为免疫评估及监测的细胞及分子标志物对于1PF诊断、病情评估和预后预测的研究潜力和临床应用潜在价值。

Idiopathic pulmonary fibrosis(IPF)is a common pulmonary interstitial disease with unknown etiology.Its pathogenesis is unknown and there is no specific drug.Its progress is urgent and its prognosis is heterogeneous.Many studies have found that abnormal immune system function of the body and lungs may be related to the pathogenesis,progression and prognosis of IPF.Combined with the literature,this paper comprehensively analyzes the distribution of IPF related immune cells,cytokines and immunoglobulins in peripheral blood and bronchoalveolar lavage fluid of IPF patients,and discusses the research potential and clinical application potential value of these cells and molecular markers as immune evaluation and monitoring for IPF diagnosis,condition evaluation and prognosis prediction.