大剂量戊酸雌二醇联合宫腔镜手术对重度宫腔粘连患者子宫内膜恢复情况的影响

Effect of High-dose Estradiol Valerate Combined with Hysteroscopic Surgery on the Recovery of Endometrium in Patients with Severe Intrauterine Adhesions

目的:探讨针对重度宫腔粘连患者应用大剂量戊酸雌二醇联合宫腔镜手术进行治疗的效果。方法:选择2019年6月至2020年6月于九江市妇幼保健院择期行宫腔镜手术的重度宫腔粘连患者76例,按随机数字表法分为两组,各38例。两组均行宫腔镜手术,对照组在此基础上应用低剂量戊酸雌二醇,观察组采用大剂量戊酸雌二醇,共治疗3个周期。对比两组临床疗效、子宫内膜厚度、不良反应发生情况、宫腔粘连复发情况。结果:观察组临床总有效率(94.74%)高于对照组(78.95%),观察组治疗后子宫内膜厚度大于对照组,子宫粘连复发率(7.89%)低于对照组(28.95%),差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:针对重度宫腔粘连患者应用大剂量戊酸雌二醇联合宫腔镜手术进行治疗的效果显著,利于增加子宫内膜厚度,减少疾病复发,且不良反应发生率较低,安全性较好。

Objective:To investigate the effect of high-dose estradiol valerate combined with hysteroscopic surgery for patients with severe intrauterine adhesions.Methods:A total of 76 patients with severe intrauterine adhesions who underwent elective hysteroscopic surgery at Jiujiang Maternal and Child Health Hospital from June 2019 to June 2020 were selected and divided into two groups according to a random number table,with 38 cases in each group.Hysteroscopic surgery was performed in both groups,the control group was treated with low-dose estradiol valerate,and the observation group was treated with high-dose estradiol valerate for a total of 3 cycles.The clinical efficacy,endometrial thickness,adverse reactions,and recurrence of intrauterine adhesions were compared between the two groups.Results:The total clinical effective rate(94.74%)of the observation group was higher than that of the control group(78.95%).The endometrial thickness of the observation group was greater than that of the control group after treatment,and the recurrence rate of uterine adhesions(7.89%)was lower than that of the control group(28.95%),All were statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of high-dose estradiol valerate combined with hysteroscopic surgery for patients with severe intrauterine adhesions has a significant effect,which is beneficial to increase the thickness of the endometrium,reduce disease recurrence,and has a low incidence of adverse reactions and good safety.