中性粒细胞/淋巴细胞水平与2型糖尿病及其动脉粥样硬化的研究

Neutrophil/Lymphocyte Level and Type 2 Diabetes and its Atherosclerosis

随着生活饮食习惯的变化,2型糖尿病发病率逐年上升。而动脉粥样硬化是糖尿病患者的大血管并发症之一,致死、致残率高,严重威胁患者的生命安全。动脉粥样硬化的发生是由于动脉管壁因脂质积聚,出现增厚、变硬现象,且血管壁弹性下降,最终发生管腔狭窄或闭塞。炎症能促进动脉粥样硬化的发生发展,从而导致血管病变的发生。中性粒细胞/淋巴细胞参与炎症反应,可反映机体的炎症水平。目前,关于中性粒细胞/淋巴细胞水平与2型糖尿病和动脉粥样硬化的研究较少,且已有研究对作用机制尚未完全明确。本文以下综述中性粒细胞/淋巴细胞水平与2型糖尿病患者并发粥样硬化的研究,以期为2型糖尿病及其血管并发症的预防和诊治提供一定参考依据。

With the changes in living and eating habits,the incidence of type 2 diabetes is increasing year by year.Atherosclerosis is one of the major vascular complications of diabetic patients,with a high rate of death and disability,which seriously threatens the lives of patients.The occurrence of atherosclerosis is due to the thickening and hardening of the arterial wall due to lipid accumulation,and the decrease of the elasticity of the blood vessel wall,and finally the lumen stenosis or occlusion occurs.Inflammation can promote the occurrence and development of atherosclerosis,leading to the occurrence of vascular disease.Neutrophils/lymphocytes are involved in the inflammatory response and can reflect the level of inflammation in the body.At present,there are few studies on the level of neutrophils/lymphocytes and type 2 diabetes and atherosclerosis,and the mechanism of action has not yet been fully clarified by existing studies.This article summarizes the study of neutrophil/lymphocyte level and atherosclerosis in patients with type 2 diabetes,in order to provide a reference for the prevention,diagnosis and treatment of type 2 diabetes and its vascular complications.