基于临床研究文献对玉屏风散证治规律的统计分析

Statistical Analysis of the Rule of Syndrome and Treatment of Yupingfeng Powder Based on Clinical Research Literatures

目的:分析玉屏风散的证治规律,包括主治病种、具体剂量、配伍药物等,为临床运用提供依据。方法:检索中国知网、维普期刊全文数据库及万方数据知识服务平台2000—2020年玉屏风散的临床研究文献,对玉屏风散的主治病种、药物用量比值、不同剂量使用频率、配伍情况等进行统计分析。结果:玉屏风散除了在呼吸系统运用外,还用于消化系统、皮肤、泌尿系统疾病的治疗。方中黄芪∶白术∶防风最常用配伍比例是2∶2∶1;黄芪与白术的用量比例范围在0.80~3.00,黄芪与防风的用量比例范围在1.00~1.33,白术与防风的用量比例范围在1.00~2.50;方中黄芪学用用量为10~30 g、白术为10~15 g、防风为6~15 g,其中防风用量比药典大,而总体用量显著低于古代用量。本方常搭配健脾、疏风、温阳类药物使用,如党参、桂枝、白芍、当归、茯苓,亦常与其他方剂如香砂六君子汤、黄芪桂枝汤、小青龙汤等联合运用。结论:玉屏风散主治病种涉及全身多个系统,疗效显著;其临床应用中配伍比例存在差异,具体用量亦无统一标准;临床中玉屏风散多为单方应用,或结合辨证加味使用。

Objective: To analyze the rule of syndrome and treatment of Yupingfeng powder, including the main diseases,specific dosage,compatible medicine,etc.,so as to provide basis for clinical application. Methods:The clinical research literatures of Yupingfeng powder from China National Knowledge Network(CNI), VIP database and Wanfang database from 2000 to 2020 were retrieved,and statistical analysis was made on the main diseases treated by Yupingfeng powder,ratio of medicine dosage,frequency of use of different doses,compatibility,etc. Results:Yupingfeng powder was not only used in the treatment of respiratory system,but also used in the treatment of digestive system,skin disease and urinary system disease. The most commonly used compatibility ratio of "Radix Astragali: Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae" in the prescriptions was 2∶ 2∶ 1;the dosage ratio of Radix Astragali and Radix Astragali ranged from 0.80 to 3.00;the dosage ratio of Radix Astragali and Radix Saposhnikoviae ranged from 1.00 to 1.33;the dosage ratio of Rhizoma Atractylodis Macrocephalae and Radix Saposhnikoviae ranged from 1.00 to 2.50. In the prescription,the specific dosage of Radix Astragali,Rhizoma Atractylodis Macrocephalae and Radix Saposhnikoviae was 10-30 g,10-15 g and 6-15 g respectively,among which the dosage of Radix Saposhnikoviae was larger than that of Chinese Pharmacopoeia, and the overall dosage was significantly lower than that of ancient times. This prescription was often combined with herbs for strengthening the spleen,scattering wind and warming yang,such as Radix Codonopsis,Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Angelicae Sinensis and Poria. It was often used in combination with other prescriptions,such as Xiangsha Liujunzi tang,Huangqi Guizhi tang and Xiaoqinglong tang. Conclusion:The main diseases treated by Yupingfeng powder involve many systems of the whole body,and the curative effect is remarkable. There are differences in the proportion of compatibility in clinical application,and there is no unified standard for specific dosage. In clinic, Yupingfeng powder is mostly used single-prescription or combined with other modified prescriptions based on syndrome differentiation.