循经推按联合脂肝合剂治疗代谢相关脂肪性肝病临床研究

Clinical Study on Pushing and Pressing Manipulation Along Meridian Combined with Zhigan Mixture for Metabolism-Related Fatty Liver Disease

目的:观察循经推按联合脂肝合剂治疗代谢相关脂肪性肝病(MAFLD)的临床疗效及对血清谷胱甘肽转移酶(GST)、游离脂肪酸(FFA)及脂联素(APN)水平的影响。方法:选取98例MAFLD患者,采用掷骰子法随机分为对照组与研究组各49例。对照组在常规治疗基础上口服脂肝合剂,研究组在对照组基础上采用循经推按穴位治疗。采用酶联免疫吸附法检测血清FFA、APN、天门冬氨酸氨基转移酶(AST)、丙氨酸转氨酶(ALT)、谷氨酰转氨酶(GGT)、GST水平;采用全自动生化分析仪检测血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平;采用放射免疫法检测血清瘦素(LP)水平。结果:治疗后,研究组总有效率为95.92%,高于对照组的81.63%(P<0.05)。与同组治疗前比较,2组血清FFA、AST、ALT、GGT、GST、TG、TC、LDL-C、LP水平均降低(P<0.05),HDL-C、APN水平均升高(P<0.05);与对照组治疗后比较,研究组治疗后血清FFA、AST、ALT、GGT、GST、TG、TC、LDL-C、LP水平均较低(P<0.05),HDL-C、APN水平均较高(P<0.05)。结论:循经推按联合脂肝合剂能有效降低血脂指标,有利于减少肝部脂肪沉积,从而减轻肝功能损伤,缓解MAFLD。

Objective:To observe the clinical effect of pushing and pressing manipulation along meridian combined with Zhigan mixture for Metabolism-related fatty liver disease(MAFLD), and its effect on levels of glutathione S-transferase(GST),free fatty acid(FFA),and adiponectin(APN) in serum. Methods:A total of 98 cases of MAFLD patients were selected and randomly divided into the control group and the study group according to the method of throwing the dice,49 cases in each group. The control group was given Zhigan Mixture orally on the basis of conventional treatment,and the study group was additionally treated with the therapy of pushing and pressing manipulation along meridian based on the treatment of the control group.The levels of FFA, APN, aspartate transaminase(AST), alanine transaminase(ALT), glutamyl transferase(GGT), and GST in serum were detected by enzyme-linked immunosorbent assay. The levels of triglyceride(TG), total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) in serum were detected by automatic biochemical analyzer. The level of leptin(LP) in serum was detected by radioimmunoassay. Results:After treatment,the total effective rate was 95.92% in the study group,higher than that of 81.63% in the control group(P<0.05). When compared with those before treatment in the same group,levels of FFA,AST,ALT,GGT,GST,TG,TC,LDL-C,and LP in serum in the two groups were decreased(P<0.05),levels of HDL-C and APN were increased(P<0.05).After treatment,levels of FFA,AST,ALT,GGT,GST,TG,TC,LDL-C,and LP in serum in the study group were lower than those in the control group(P<0.05),and levels of HDL-C and APN were higher(P<0.05). Conclusion:The therapy of pushing and pressing manipulation along meridian combined with Zhigan mixture effectively reduces blood lipid indexes and conduces to decrease of fat deposition in the liver,thus relieving the liver function injury and MAFLD.