2008-2020年山东省健康人群脑膜炎奈瑟菌携带特征分析

Analysis of Neisseria Meningitidis carriage characteristics among healthy population in Shandong province from 2008 to 2020

目的分析山东省健康人群脑膜炎奈瑟菌(Nm)的携带特征。方法于2008年4月至2020年4月,以济南市历下区、潍坊市高密市、济宁市嘉祥县、威海市文登区、临沂市郯城县、德州市临邑县6个地区为研究现场,招募16848名健康人群为研究对象开展调查。采集研究对象咽拭子标本,对Nm进行分离培养鉴定,分析不同特征研究对象的Nm携带特征。结果16848名研究对象中男性占51.86%(8737名);共分离到Nm菌株136株,携带率为0.81%。136株Nm菌株以B群(60.29%)和不可分群菌株(23.53%)为主;临沂(1.39%)和济南市(1.14%)的健康人群Nm菌株携带率较高;13~16岁(1.60%)、17~19岁(1.10%)年龄组人群的Nm菌株携带率较高;男性携带率(1.02%)较高。结论山东省健康人群Nm携带率相对较低,B群和不可分群Nm的占比较高。

Objective To analyze the carriage characteristics of Neisseria meningitidis(Nm)among healthy population of epidemic cerebrospinal meningitis in Shandong province.Methods From April 2008 to April 2020,a total of 16848 healthy population were recruited from Lixia District of Jinan City,Gaomi City of Weifang City,Jiaxiang County of Jining City,Wendeng District of Weihai City,Tancheng County of Linyi City and Linyi County of Dezhou City for the investigation.Throat swab samples were collected,Nm was isolated,cultured and identified,and Nm carrying characteristics of healthy population with different characteristics were analyzed.Results Among the 16848 healthy population,male accounted for 51.86%(8737).A total of 136 Nm strains were isolated,and the carriage rate was 0.81%.Among the 136 Nm strains,serogroup B(60.29%)and ungroupable strains(23.53%)were dominant.Analysis of the Nm carriage rate,that were higher in the healthy population of Linyi(1.39%)and Jinan(1.14%),higher in 13-16 years old(1.60%)and 17-19 years old(1.10%)healthy population,and higher in male(1.02%).Conclusion The Nm carriage rate of healthy population is relatively low in Shandong Province,and the proportion of serogroup B and ungroupable Nm is relatively high.