共聚维酮改善金银花粉末压缩成型性能的研究

Improving compactibility properties of Lonicera Japonica Flos by Plasdone S-630

本文通过研究粒子修饰技术改善中药生粉类药材的流动性和压缩成型性,为满足下一步制剂制备的需求。以金银花粉末作为模型药物,采用流化床底喷技术,使用共聚维酮作为修饰剂,制备修饰粒子;分别测定各粉体的粉体学性质、片剂压缩成型参数以及崩解时限和溶出度,并结合扫描电镜技术对修饰前后粉体粒子和压制的片剂表面形态进行表征。结果表明,经过粒子修饰后,金银花粉体粒子粒径增大,其粉体的流动性、可压缩性以及成型性均得到一定的改善,并且其崩解时限也有一定的降低,体外溶出度也不受影响。因此,本研究可以为中药生粉类药材因流动性、可压性等粉体属性较差而不能满足制剂生产需要这一共性问题提供参考和思路。

To improve the fluidity and compactibility properties of raw powders of traditional Chinese medicine by particle modification technology,Lonicera Japonica Flos was used as a model drug,fluidized bed bottom spray technology was used,and Plasdone S-630 was used as amodifier to preparemodified particles.The powder properties,tablet compactibility parameters,disintegration time and dissolution were measured.The surface morphology of the powder particles before and after modification and compressed tablets were characterized by combining with scanning electron microscopy technology.The results showed that the particle size of Lonicera Japonica powder has been increased after particle modification,the fluidity,compressibility and compactibility of the powder have been improved to some extent,the disintegration time has also been reduced,and the dissolution in vitro is not affected.Therefore,this study can provide reference and ideas for the common problem that raw powder of traditional Chinese medicine that cannot meet the needs of preparation production due to poor powder properties such as fluidity and compressibility.