昼夜节律的相关研究进展

Research progress of circadian rhythm

在生活中由于时差、轮班工作、睡眠中断和食物消耗的变化,导致了昼夜节律失调的现象在社会中非常普遍。光是影响昼夜节律系统的最主要因素,昼夜节律系统的破坏会对机体造成损伤,从而引起一些疾病。维持正常的昼夜节律系统对健康有着非常重要的意义,理想的治疗效果不仅可以使疾病的症状发生缓解,而且应当使紊乱的昼夜节律恢复正常。该文以文献综述的方式,总结了昼夜节律紊乱动物模型的造模方法,昼夜节律异常的疾病,与昼夜节律相关的生物钟基因和药物对昼夜节律紊乱疾病的调节。

Circadian rhythm disorder is a common society issue caused by jet lag,shift work,sleep disruption and changes in food consumption.Light is the major factor affecting the circadian rhythm system.Disruption of the circadian rhythm system can cause damage to the body,leading to some diseases.Maintaining a normal circadian system is of great importance for good health.Ideal therapeutic effect can not only alleviate symptoms of the diseases,but also recovery the disturbed circadian rhythm to normal.The paper summarizes the modeling methods of animal circadian rhythm disorder,diseases of circadian rhythm abnormality,regulation of circadian clock genes and medicine which are related to circadian rhythm to diseases of circadian rhythm disorder.