蒜香藤中2个新的吡喃并萘醌类化合物

Two new pyranonaphthoquinones from Mansoa alliacea

蒜香藤原产南美洲的热带雨林地区,现在我国华南地区有引种,具多种药理活性,但目前对其化学成分的研究报道较少。该研究运用硅胶、十八烷基键合硅胶(ODS)、葡聚糖凝胶(Sephadex LH-20)、制备型高效液相色谱(PHPLC)等多种现代色谱技术,从蒜香藤枝叶95%乙醇提取物中分离得到2个化合物,并通过紫外光谱(UV)、红外光谱(IR)、高分辨质谱(HRESI-MS)和一维及二维核磁共振技术(NMR)等多种谱学方法,鉴定它们的结构分别为8,9-dimethoxy-α-lapachone(1)和7-hydroxy-8,9-dimethoxy-α-lapachone(2),为2个新的吡喃并萘醌类化合物,并分别命名为蒜香藤素甲(mansonin A,1)和蒜香藤素乙(mansonin B,2)。

Mansoa alliacea,commonly known as garlic vine,is native to the tropical rain forests of South America and widely cultivated in South China.As a popular folk medicine with various biological activities,however,this plant remains to be fully elucidated in terms of its phytochemical constituents.In this study,two new pyranonaphthoquinones were isolated from the 95%ethanol extract of the leaves and twigs of M.alliacea by various chromatographic approaches including silica gel,octadecyl silica(ODS),Sephadex LH-20,and preparative high-performance liquid chromatography(PHPLC).Their structures were determined to be 8,9-dimethoxy-α-lapachone(1)and 7-hydroxy-8,9-dimethoxy-α-lapachone(2)by comprehensive spectroscopic analyses and therefore respectively named as mansonin A(1)and mansonin B(2).