中国成人睑板腺功能障碍与体质指数的相关性

Association between meibomian gland dysfunction and body mass index in Chinese adults

目的探讨中国成人睑板腺功能障碍(MGD)与体质指数(BMI)的相关性。方法2013年5至10月,在33家医院的眼表疾病门诊收集2419例患者资料,其中男780例(32.2%),女1639例(67.8%),年龄18~89(46±16)岁,根据BMI将患者分为体重过低组、体重正常组、超重组和肥胖组,同时进行右眼睑板腺相关检查和评分。结果体重过低组、体重正常组、超重组和肥胖组分别为196、1556、567和100例。与体重正常组相比,超重组和肥胖组中重度MGD的比例明显较高(59.1%、71.0%比49.9%),差异均有统计学意义(均P<0.05)。超重组和肥胖组的睑缘改变评分、睑板腺分泌能力评分和睑板腺分泌物性状评分明显高于体重正常组,差异均有统计学意义(均P<0.05)。按年龄分层,在青年组中,肥胖人群的以上3项评分均高于体重正常组,差异均有统计学意义(均P<0.05)。多项logistic回归分析结果显示,与体重正常相比,超重和肥胖与中重度MGD相关,OR值分别为2.19(95%CI:1.06~4.50,P=0.033)和3.70(95%CI:2.57~5.04,P=0.008)。结论中国成人中重度MGD与高BMI具有明显相关性。

Objective To evaluate the association of meibomian gland dysfunction(MGD)and body mass index(BMI)in Chinese adults.Methods A total of 2419 patients were retrospectively recruited between May and October 2013 from 33 ocular surface disease clinic in China.There were 780 males(32.2%)and 1639 females(67.8%),aged 18-89(46±16)years.BMI value of each patient was respectively calculated,and the patients were divided into underweight,normal weight,overweight and obesity groups accordingly.Meibomian gland-related examinations were performed in right eyes.Results The number of the patients in four groups were 196,1556,567 and 100,respectively.Compared with normal weight group,the rates of moderate to severe MGD(59.1%,71.0%vs 49.9%)in overweight group and obesity group were higher,and the differences were statistically significant(both P<0.05).The scores of change in eyelid margin,meibomian gland dropout and meibum expressibility were significantly higher in overweight group and obesity group,compared with normal weight group(all P<0.05).Additionally,after stratified by age,all the above-mentioned three scores of obese patients were significantly higher than those of non-obese patients in young adult group.Multivariate logistic regression analysis showed that moderate to severe MGD was correlated with overweight(OR=2.19,95%CI:1.06-4.50,P=0.033)and obesity(OR=3.70,95%CI:2.57-5.04,P=0.008).Conclusion Moderate to severe MGD significantly correlates with high BMI in Chinese adults.