益气宣肺汤治疗老年功能性便秘气虚证临床研究

Clinical study on Yiqi Xuanfei decoction in treating functional constipation with Qixu syndrome in old age

目的:探究益气宣肺汤治疗老年功能性便秘气虚证的临床疗效。方法:选择老年功能性便秘气虚证患者80例,分为益气宣肺汤组、乳果糖组,每组40例。益气宣肺汤组患者给予益气宣肺汤,乳果糖组患者口服乳果糖液,两组患者均治疗4周。比较两组患者治疗前后的临床疗效、便秘症状积分、平均每周自发完全排便次数(ANSCD)及生活质量评分。结果:治疗结束后,益气宣肺汤组总有效率100%,高于乳果糖组的82.5%,差异有统计学意义(P<0.05)。益气宣肺汤组的显著有效率为90.0%,高于乳果糖组的42.5%,差异有统计学意义(P<0.01)。治疗后,两组便秘症状积分均降低、ANSCD则增加,组内比较差异有统计学意义(均P<0.05)。治疗后,益气宣肺汤组便秘症状积分低于乳果糖组,差异有统计学意义(P<0.05)。两组治疗后生活质量评分的各项指标较治疗前均改善,且益气宣肺汤组治疗后生活质量评分的各项指标均优于乳果糖组,差异有统计学意义(均P<0.05)。结论:益气宣肺汤治疗老年功能性便秘气虚证效果优于乳糖液,可改善患者生活质量,减轻伴随症状。

Objective:To study the efficacy of Yiqi Xuanfei decoction in the treatment of functional constipation with Qixu syndrome.Methods:80 elderly patients of functional constipation with Qixu syndrome were divided into Yiqi Xuanfei decoction group and lactulose group,40 cases in each group.The Yiqi Xuanfei decoction group was given Yiqi Xuanfei decoction,and the lactilose group given lactose solution orally.Both groups were treated for 4 weeks.Clinical efficacy,constipation symptom score,average number of spontaneous complete defecation(ANSCD)per week,quality of life scores were compared between the two groups.Results:After treatment,the total effective rate of the Yiqi Xuanfei decoction group was 100%,which was higher than 82.5%of the lactilose group,difference statistical significant(P<0.05).The significant effective rate of the Yiqi Xuanfei decoction group was 90.0%,which was higher than 42.5%in the lactilose group,difference statistically significant(P<0.01).After treatment,constipation symptom scores in both groups decreased,while ANSCD increased,with statistical significance in the two groups(all P<0.05).After treatment,the score of constipation symptom in the Yiqi Xuanfei decoction group was lower than that in the lactilose group,and the difference between the two groups was statistically significant(P<0.05).After treatment,the indicators of quality of life score in the two groups were improved compared with before treatment,and indicators of quality of life score in the Yiqi Xuanfei decoction group was better than that in the lactilose group,with statistical significance(all P<0.05).Conclusion:Yiqi Xuanfei decoction in the treatment of functional constipation with Qixu syndrome in elderly patients is better than lactose solution,and can improve the quality of life,reduce accompanying symptoms.