抗青光眼滤过手术后瘢痕化的研究进展

Research progress on anti-scarring after glaucoma filtration surgery

青光眼滤过手术是目前药物及激光治疗以外重要治疗方式,其目的在于形成功能性滤过通道,从而充分引流房水。但青光眼术后巩膜纤维化和结膜下滤泡瘢痕化是导致手术失败的重要原因。现从青光眼滤过手术后抗代谢药物、植入物应用、靶向机制、新型生物分子材料应用及表观遗传学研究5个方面来综合分析青光眼滤过手术后抗瘢痕化的进展现状。

Glaucoma filtration surgery is an important treatment method besides drug and laser therapies.Its purpose is to form a functional filtering channel to fully drain aqueous humor.However,scleral fibrosis and subconjunctival follicle scarring after the surgery are important causes of surgical failure.This paper about anti-scaring after the glaucoma filtration surgery is structured from five aspects:antimetabolites,implant applications,targeting mechanisms,novel biomolecular materials applications,and epigenetic studies.