骨缺损动物模型的研究进展

Research Progress in Animal Models of Bone Defects

骨缺损达到一定范围及距离后,机体自身无法自行修复,即临界骨缺损,需自体骨移植、异体骨移植或骨组织工程进行修复。骨缺损动物模型常被用以评估骨组织工程中骨替代生物材料的再生能力。本文概述了近年来常用的动物骨缺损模型和目前可应用的研究方向,并阐述了口腔相关动物骨缺损模型的现状。

After the bone defect reaches a certain range and distance,the body cannot repair itself,that is,the critical bone defect,which requires autogenous bone transplantation,allogeneic bone transplantation or bone tissue engineering to repair.Animal models of bone defects are often used to evaluate the regeneration capacity of bone substitute biomaterials in bone tissue engineering.This article summarizes the animal bone defect models commonly used in recent years and their current research directions,and focuses on oral animal bone defect models.