移植肾复发和新发局灶节段性肾小球硬化的研究进展

Update on recurrent and de novo focal segmental glomerulosclerosis after kidney transplantation

局灶节段性肾小球硬化(FSGS)是成人及儿童肾病综合征的常见病理类型之一。肾移植术后FSGS易复发,且导致移植肾失功风险增加。近年来,对于移植后FSGS复发机制的研究逐渐深入,而移植后新发FSGS也引起关注,其发病机制和治疗方法与复发性FSGS有所不同。文章就移植肾复发和新发FSGS的发病机制、临床病理表现、治疗和预后的研究进展进行综述。

Focal segmental glomerulosclerosis(FSGS)is a common pathological pattern of nephrotic syndrome in adults and children.FSGS tends to recur in renal allografts and leads to an increased risk of allograft loss.In recent years,the research on the pathogenesis of recurrent FSGS has gradually deepened,and de novo FSGS after transplantation has also raised attention.The pathogenesis and treatment of de novo FSGS are different from those of recurrent FSGS.This review summarizes the pathogenesis,clinicopathological features,treatment and prognosis of recurrent and de novo FSGS after kidney transplantation.