多形核中性粒细胞在脑出血继发性损伤中的研究进展

Progress of polymorphonuclear neutrophils in secondary injury of cerebral hemorrhage

脑出血是脑卒中第二大类型,有着高致残率和高死亡率。研究表明,外周血中性粒细胞与淋巴细胞的比率升高可预示脑出血患者的不良预后。而活体显微镜检查和免疫组化明确地揭示了多形核中性粒细胞(PMNs)在出血性脑实质中的积累,可推测在脑出血继发性损伤过程中,PMNs引起的炎症反应影响甚大。PMNs亦存在类似小胶质细胞表型的概念,分为促炎型N1和抗炎型N2 PMNs。文章结合近年相关研究对PMNs及其相关分子在脑出血继发性损伤中的作用和机制进行综述。

Intracerebral hemorrhage(ICH)is the second largest type of stroke,with high morbidity and mortality.Studies have shown that the increase of neutrophils and lymphocyte in peripheral blood can predict the poor prognosis of patients with intracerebral hemorrhage.The result of vivo microscopy and immunohistochemistry clearly revealed the accumulation of polymorphonuclear neutrophils(PMNs)in hemorrhagic brain parenchyma,which indicated that the inflammatory reaction caused by PMNs has a great influence on the secondary injury of intracerebral hemorrhage.Recently,it has been reported that PMNs also have the concept of microglial phenotype,which can be divided into pro-inflammatory N1 and anti-inflammatory N2 polymorphonuclear neutrophils.In this paper,we reviewed the role and mechanism of PMNs and its related molecules in cerebral hemorrhage injury.