非酒精性脂肪性肝病动物模型研究进展

Models of nonalcoholic fatty liver disease

目的非酒精性脂肪性肝病(NAFLD)发病率逐年增加,并可能发展成为终末期肝病。目前,仍缺乏针对该病的治疗药物,建立动物模型研究很有必要。尽管已有多种不同种类的疾病模型,但仍没有一种能真正反映人类整个疾病谱的代表性的NAFLD模型。本文对目前应用的NAFLD模型进行了综述,重点介绍动物模型、2D细胞模型和3D肝脏模型及其优缺点。

Objective The incidence rate of nonalcoholic fatty liver disease(NAFLD)is increasing.It might progress to the end-stage liver disease.However,there is still no specific treatment for this entity.Therefore,the establishment of representative animal models reflecting disease characteristics has become especially important.Although there are many different disease models,there is still a lack of NAFLD model which could cover the whole spectrum of this entity in human.In this paper,we reviewed the current progress on NAFLD model,focusing on animal model,2D cell model,3D liver model and their advantages and disadvantages.