阻止不溶微粒的精密药液过滤器的研制与应用

Research and application of precision liquid medicine filter for preventing insoluble particles

目的旨在消除在静脉或肌肉注射药物中的不溶颗粒以及打破玻璃安剖产生的微粒对人体的伤害。方法研制一种阻止不溶微粒的注射筒内部放置药液过滤器。过滤器前端为锥形端,后端为过滤端;过滤器本体包括过滤块和其内部的浮塞,过滤块内侧形成过滤腔,过滤腔内设置环形过滤膜。注射器抽液时,浮塞移动至过滤块的浮塞通道顶部,液体从浮塞的盲孔进入过滤腔;注射器排液时,浮塞远离过滤块的浮塞通道顶部,过滤腔的液体经过环形过滤膜、过滤块外围通道进入浮塞的盲孔,并测试滤过效果。结果过滤器的核孔膜、聚醚砜膜和尼龙膜对5μm乳胶粒子标准溶液中5~6μm粒子数的滤除率分别达96.9%、97.1%和96.2%。核孔膜对3μm乳胶粒子标准溶液中3~4μm粒子数的滤除率达98.1%。结论本过滤器能够滤过药物内微粒和沉淀,达到过滤的效果,确保患者用药安全。

Objective To eliminate the insoluble particles in the drug and the particles produced by breaking the glass during intravenous or intramuscular injection.Methods We established a type of liquid medicine filter for preventing insoluble particles in this study.The front end of the filter body was conical and the back end was a filtering one.The filter body consisted of a filter block and a floating plug arranged inside the filter block.A filter chamber was formed inside the filter block,and a ring-shaped filter membrane was set in the filter chamber.When the injector pumped liquid,the float plug moved to the top of the float plug channel of the filter block,and the liquid entered the filter cavity from the blind hole of the float plug.When the syringe discharged liquid,the float plug was far away from the top of the float plug channel of the filter block,and the liquid in the filter cavity entered the blind hole of the float plug through the annular filter membrane and the peripheral channel of the filter block.Results The filtration rates of 5‒6μm particles in standard solution of 5μm latex particles by nuclear pore membrane,polyethersulfone membrane and nylon membrane were 96.9%,97.1%and 96.2%,respectively.The filtration rate of 3‒4μm particles in the standard solution of 3μm latex particles could reach 98.1%.Conclusion The filter can filter the particles,which precipitate in the drug,thus achieving the effect of filtration and ensuring the safety of patients.