成人脓毒症与肠道菌群失衡的相关性研究

Study on correlation between sepsis and imbalance of intestinal flora in adults

目的分析成人脓毒症与肠道菌群失衡的相关性。方法选择2017年1月至2019年12月期间75例脓毒症患者及同期24名健康体检者为研究对象,分别设为患者组、健康组,其中患者组依据其病情严重程度分为脓毒症组45例、脓毒症休克组30例,均实施粪便菌群检测,评价成人脓毒症与肠道菌群的相关性。结果患者组肠道菌群失衡[B/E(双歧杆菌/肠杆菌)]<1占比为80.00%,较健康组(25.00%)高(P<0.01);患者组中脓毒症组、脓毒症休克组肠道菌群失衡占比分别为73.33%、90.00%;健康组、脓毒症组、脓毒症休克组B/E值比较,差异有统计学意义(P<0.001),脓毒症休克组B/E值低于脓毒症组(P<0.05);脓毒症患者病情严重程度与B/E比值水平呈负相关(Kendall’s tau-b=-0.439,P<0.001)。结论成人脓毒症严重程度与肠道菌群失衡呈现相关性。

Objective To analyze correlation between sepsis and the imbalance of intestinal flora in adults.Methods 75 patients with sepsis from January 2017 to December 2019 and 24 healthy people who underwent physical examination during the same period were selected for the study.They were divided into patient group and healthy group,among which the patient group were divided into sepsis group(n=45)and sepsis shock group(n=30)according to the severity of the disease,and all of which were given fecal flora testing to evaluate the correlation between sepsis and intestinal flora in adults.Results The percentage of intestinal flora imbalance(bifidobacterium/enterobacteriaceae[B/E]<1)in the patient group was 80.00%,which was higher than that in the healthy group(25.00%)(P<0.01);the percentage of intestinal flora imbalance in the sepsis group and the sepsis shock group was 73.33%and 90.00%,respectively(P<0.05);the difference of the B/E ratio of the healthy group,the sepsis group and the sepsis shock group was statistically significant(P<0.001),and that of the sepsis shock group was lower than that of the sepsis group(P<0.05);the severity of sepsis patients was negatively correlated with the level of B/E ratio(Kendall’s tau-b=-0.439,P<0.001).Conclusion The severity of sepsis in adults is correlated with the imbalance of intestinal flora.