缓释氟尿嘧啶植入剂联合腹腔镜胃癌D2根治术对进展期老年胃癌患者近期疗效及对CEA、VEGF水平的影响

Effect of Sustained-release Fluorouracil Implant Combined with Laparoscopic D2 Radical Gastrectomy on the Short-term Efficacy and the Levels of CEA and VEGF in Elderly Patients with Advanced Gastric Cancer

目的:探讨缓释氟尿嘧啶植入剂联合腹腔镜胃癌D2根治术对进展期老年胃癌患者治疗效果,以及CEA、VEGF水平与术后恢复情况的影响。方法:随机将本院2019年12月-2020年12月收治的80例进展期老年胃癌患者分为观察组(n=40)和对照组(n=40),对照组采用腹腔镜胃癌D2根治术,观察组在此基础上加用缓释氟尿嘧啶植入剂。比较两组近期疗效、癌胚抗原(CEA)、血管内皮因子(VEGF)水平、不良反应及术后恢复情况。结果:观察组总有效率高于对照组(P<0.05);比较两组患者CEA、VEGF水平,与治疗前相比,治疗后两组CEA、VEGF均有所降低,但观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,但差异无统计学意义(P>0.05);两组术后胃肠功能恢复时间比较差异无统计学意义(P>0.05),但观察组住院时间短于对照组(P<0.05)。结论:缓释氟尿嘧啶植入剂联合腹腔镜胃癌D2根治术缩短进展期老年胃癌患者的住院时间,抑制病情发展,促进患者康复,疗效安全可靠。

Objective:To investigate the therapeutic effect of Sustained-release Fluorouracil Implant combined with laparoscopic D2 radical gastrectomy on elderly patients with advanced gastric cancer and the influence of CEA,VEGF levels and postoperative recovery.Method:A total of 80 elderly patients with advanced gastric cancer in our hospital from December 2019 to December 2020 were randomly divided into the observation group(n=40)and the control group(n=40).The control group was treated with laparoscopic D2 radical gastrectomy,and the observation group was treated with Sustained-release Fluorouracil Implant on this basis.The short-term efficacy,CEA,VEGF levels,adverse reactions and postoperative recovery were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).The levels of CEA and VEGF in the two groups were compared,after treatment,the levels of CEA and VEGF in the two groups were decreased,but the levels in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,but the difference was not statistically significant(P>0.05).There was no significant difference in the recovery time of gastrointestinal function between the two groups(P>0.05),but the hospitalization time of the observation group was shorter than that of the control group(P<0.05).Conclusion:Sustained-release Fluorouracil Implant combined with laparoscopic D2 radical gastrectomy can shorten the hospitalization time of elderly patients with advanced gastric cancer,inhibit the development of the disease,promote the recovery of patients,and the curative effect is safe and reliable.