不同剂量布地奈德联合地塞米松对小儿急性感染性喉炎的影响

Effects of Different Doses of Budesonide Combined with Dexamethasone in the Treatment of Children with Acute Infectious Laryngitis

目的:探讨小儿急性感染性喉炎给予不同剂量布地奈德联合地塞米松治疗的临床效果。方法:选取2018年1月-2021年1月笔者所在医院收治的84例急性感染性喉炎患儿作为研究对象,按照随机数字表法将其分为观察组(42例)和对照组(42例)。对照组给予小剂量布地奈德联合地塞米松治疗,观察组给予大剂量布地奈德联合地塞米松治疗。比较两组临床疗效、症状消退时间、炎性因子水平、不良反应。结果:两组治疗总有效率比较差异无统计学意义(P>0.05)。两组发热、咳嗽、呼吸困难、声音嘶哑等症状消退时间均早于对照组,差异有统计学意义(P<0.05)。两组治疗后超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均较治疗前明显降低(P<0.05),但两组治疗后hs-CRP、IL-6、TNF-α水平比较差异无统计学意义(P>0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:大剂量布地奈德联合地塞米松治疗小儿急性感染性喉炎可缩短患儿发热、咳嗽、呼吸困难、声音嘶哑等症状消退时间,且药物安全性较高,值得推广应用。

Objective:To investigate the clinical effect of different doses of Budesonide combined with Dexamethasone in the treatment of children with acute infectious laryngitis.Method:A total of 84 children with acute infectious laryngitis treated in our hospital from January 2018 to January 2021 were selected as the research objects,and they were divided into the observation group(42 cases)and the control group(42 cases)according to the random number table method.The control group was given low-dose Budesonide combined with Dexamethasone,and the observation group was given high-dose Budesonide combined with Dexamethasone.Clinical efficacy,symptom regression time,inflammatory factor levels and adverse reactions were compared between the two groups.Result:There was no significant difference in the total effective rate between the two groups(P>0.05).The regression time of symptoms such as fever,cough,dyspnea and hoarseness in the observation group were earlier than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were significantly decreased compared with those before treatment(P<0.05),but there were no statistical significances in the levels of hs-CRP,IL-6 and TNF-αbetween the two groups after treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:High-dose Budesonide combined with Dexamethasone in the treatment of children with acute infectious laryngitis can shorten the symptom regression time of fever,cough,dyspnea,hoarseness and other symptoms,and the drug safety is high,which is worthy of promotion and application.