骨伤科疾病患者的痛风患病率调查与流行病学研究

Prevalence and epidemiology of gout in patients with orthopedic diseases *

目的通过调查广东地区骨伤科疾病人群的痛风患病率及流行病学研究,以对该类人群的痛风患病建立风险评估、预测预警等诊治方案应用于临床决策系统。方法回顾2020年1月1日至8月31日在该院骨伤科就诊的人群85254例,排除严重肾功能损害者,对最终入组的84794例研究对象行痛风及相关疾病横断面调查,并对相关结果进行统计学分析。结果骨伤科疾病人群中痛风的患病率为6.4%(5427/84794)。男性的发病年龄(中位数41岁)明显比女性要提前(中位数58岁);男性痛风患病率为10.6%,明显高于女性的1.1%;痛风患者中合并高血压、血脂异常、肝病比例明显高于非痛风患者。上述结果组间比较差异均有统计学意义(P<0.05)。结论痛风在骨伤科疾病人群的患病率明显升高,且比非痛风患者更易合并肝病、各类心脑血管病及代谢性疾病。

Objective By investigating the prevalence and epidemiology of gout in orthopaedic disease population in Guangdong area,the risk assessment,prediction and early warning and other prevention and treatment programs were established to apply to the clinical decision-making system.Methods A retrospective review was made of 85254 patients who visited the hospital from January 1 to August 31,2020,patients with severe renal impairment were excluded.A cross-sectional survey on gout and related diseases of 84794 subjects was conducted on the enrolled subjects,and the relevant results were statistically analyzed.Results The prevalence of gout in the orthopaedic population was 6.4%(5427/84794).The median age of male patients was 41 years old,and that of female patients was 58 years old,significantly earlier in men than in women;the prevalence of gout in men(10.6%)was significantly higher than that in women(1.1%);the patients with gout complicated with hypertension,hyperlipidemia and liver disease were significantly higher than those without gout.There were statistically significant differences in the above results among groups(P<0.05).Conclusion The prevalence of gout in orthopaedic patients is significantly increased,and the patients are more likely to be complicated with liver disease,various cardiovascular and cerebrovascular diseases and metabolic diseases than those without gout.