新入院流浪精神病患者的心肌酶谱分析

Myocardial Enzyme of Newly Hospitalized Homeless Psychiatric Patients

目的:分析新入院流浪精神病患者的心肌酶谱检测结果及其临床意义。方法:回顾性选取本院2018年8月-2020年8月收治新入院流浪精神病患者200例作为研究对象,收集患者临床资料,分别在治疗前、治疗2周、治疗4周时检测患者血清心肌酶谱水平,同时采用简明精神量表(BPRS)和阳性与阴性症状量表(PANSS)评估病情程度,进一步应用Pearson相关分析心肌酶谱水平与病情程度的相关性。结果:患者治疗前血清肌酸磷酸激酶(CK)、肌激酶同工酶(CK-MB)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)水平均异常升高,治疗2周和治疗4周后心肌酶谱水平明显下降(P<0.05),其中治疗4周后心肌酶谱下降水平显著低于治疗2周(P<0.05);治疗2周和治疗4周后BPRS及PANSS评分均明显比治疗前低(P<0.05),且治疗4周后BPRS及PANSS评分显著低于治疗2周(P<0.05);CK、CK-MB和LDH水平分别与BPRS、PANSS评分呈正相关(P<0.05)。结论:随着治疗时间的延长,心肌酶谱水平和BPRS及PANSS评分逐渐下降或接近正常,治疗过程中监测患者心肌酶谱有助于准确判断病情严重程度,其水平变化对预测和评估精神病患者病情及疗效具有重要意义。

Objective:To analyze the myocardial enzyme and its clinical significance in newly hospitalized homeless psychiatric patients.Method:A total of 200 newly hospitalized psychiatric patients in our hospital from August 2018 to August 2020 were retrospectively selected as the research objects,the clinical data of the patients were collected,and the serum myocardial enzyme spectrum levels before treatment,2 weeks of treatment,and 4 weeks of treatment were detected,at the same time,the brief psychiatric rating scale(BPRS)and the positive and negative syndrome scale(PANSS)were used to assess the degree of illness,and Pearson correlation was further used to analyze the correlation between the level of myocardial enzyme spectrum and the severity of the disease.Result:The serum levels of serum creatine phosphokinase(CK),muscle kinase isoenzyme(CK-MB),aspartate transaminase(AST),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH)were all abnormally increased before treatment,and the levels of myocardial enzyme spectrum were significantly decreased after 2 weeks and 4 weeks of treatment(P<0.05),among them,the decreased level of myocardial enzyme spectrum after 4 weeks of treatment were significantly lower than those of 2 weeks of treatment(P<0.05).After 2 weeks of treatment and 4 weeks of treatment,the BPRS and PANSS scores were significantly lower than before treatment(P<0.05),and after 4 weeks of treatment,the BPRS and PANSS scores were significantly lower than 2 weeks of treatment(P<0.05).The levels of CK,CK-MB and LDH were positively correlated with BPRS and PANSS scores respectively(P<0.05).Conclusion:With the extension of the treatment time,the myocardial enzyme spectrum level,BPRS and PANSS score gradually decreased or approach normal,monitoring the patients’myocardial zymogram during the treatment process can help accurately determine the severity of the disease,and its level changes are useful for predicting and evaluating the condition of mental patients and the efficacy is of great significance.