血清糖类抗原199、糖类抗原50及癌胚抗原联合粪便检测对诊断直肠癌临床意义

The Clinical Significance of Serum Carbohydrate Antigen 199,Carbohydrate Antigen 50 and Carcinoembryonic Antigen Combined with Stool Detection in the Diagnosis of Rectal Cancer

目的:分析血清糖类抗原199(CA199)、糖类抗原50(CA50)及癌胚抗原(CEA)联合粪便检测对诊断直肠癌临床意义。方法:选取2017年1月-2020年10月本院接收的80例直肠癌患者和80例健康体检者作为此次研究对象,80例直肠癌患者纳入研究组,而80例健康体检者纳入对照组。予以两组进行CA199、CA50、CEA和粪便检测,比较两组的CA199、CA50、CEA水平和粪便检测结果,观察CA199+CA50+CEA+粪便检测在直肠癌诊断中的价值。结果:研究组的CA199、CA50、CEA水平明显高于对照组(P<0.05);研究组的细条样粪便、血便、黏液便、脓血便、隐血试验阳性占比高于对照组(P<0.05);80例直肠癌患者中,CA199+CA50+CEA+粪便检测的阳性检出率96.25%,高于CA199+粪便检测的67.50%、CA199+CA50+粪便检测的78.75%(P<0.05)。结论:在直肠癌诊断中采用CA199、CA50、CEA联合粪便检测,能获得较高的诊断准确率,应用价值显著。

Objective:To analyze the clinical significance of serum carbohydrate antigen 199(CA199),carbohydrate antigen 50(CA50)and carcinoembryonic antigen(CEA)combined with stool detection in the diagnosis of rectal cancer.Method:From January 2017 to October 2020,80 patients with rectal cancer and 80 healthy subjects were selected as the subjects of this study.80 patients with rectal cancer were included in the study group,and 80 healthy subjects were included in the control group.The two groups were tested for CA199,CA50,CEA and stool,and the levels of CA199,CA50,CEA and stool test results were compared between the two groups,CA199+CA50+CEA+stool test in the diagnosis of rectal cancer value was observed.Result:The levels of CA199,CA50 and CEA in the study group were significantly higher than those in the control group(P<0.05).The proportion of positive test of thin strips of stool,blood,mucus,pus and blood,and occult blood in the study group was higher than that in the control group(P<0.05).Among 80 patients with rectal cancer,the positive detection rate of CA199+CA50+CEA+stool test was 96.25%,which was higher than 67.50%of CA199+stool test and 78.75%of CA199+CA50+stool test(P<0.05).Conclusion:The use of CA199,CA50,CEA combined with stool detection in the diagnosis of rectal cancer can obtain a higher diagnostic accuracy rate and has significant application value.