成都市新型冠状病毒感染境外输入患者与相关本土患者的临床分析

Clinical characteristics of overseas imported and related local COVID-19 patients in Chengdu

目的探讨成都市新型冠状病毒感染境外输入与相关本土患者的临床特征。方法纳入2020年11~12月成都市公共卫生临床医疗中心收治的临床诊断为新型冠状病毒无症状感染者及确诊为新型冠状病毒肺炎的中国籍境外输入型患者50例与相关本土患者14例,比较两组临床资料,统计并分析两组患者的流行病学特征、临床特征、辅助检查、治疗及预后。结果成都本土相关患者较境外输入患者年长,多为老年人、女性(P≤0.05);合并心脏病及肿瘤的比例高;有咳嗽、发热、咳痰症状的患者更多(P≤0.05)。本土相关患者C反应蛋白、空腹血糖、纤维蛋白原测定高于境外输入患者,淋巴细胞计数、血小板计数、CD3^(+)T淋巴细胞计数、CD4^(+)T淋巴细胞计数、CD8^(+)T淋巴细胞计数、肌酐检测值低于同期境外输入患者(P≤0.05);境外输入患者新型冠状病毒总抗体、IgG抗体、IgM抗体阳性检出率均较本土患者高(P≤0.05)。境外输入患者中位核酸阴转时间短于本土患者(P≤0.05)。结论本次成都市新型冠状病毒感染境外输入患者与相关本土患者在性别、年龄、共病、临床表现、淋巴细胞计数、T淋巴细胞计数、核酸阴转时间等方面存在差异,相关本土患者高龄居多,病情更复杂,但均预后良好。

Objective To study the clinical characteristics of overseas imported and related local COVID-19 patients in Chengdu.Methods Fifty overseas imported patients who were Chinese and 14 related local patients with COVID-19 who were admitted to Public Health Clinical Center of Chengdu from November to December 2020 were selected.The epidemiological characteristics,clinical manifestations,auxiliary examination,treatment and prognosis were summarized and analyzed.Results The local group were older,and they were mostly elderly and females(P≤0.05).Compared with the imported group,the proportion of the local group was higher in heart disease and tumor.More patients had cough,fever and expectoration symptoms(P≤0.05).C-reactive protein,fasting blood glucose and fibrinogen were higher,and the lymphocyte count,blood platelet count,CD3^(+)T lymphocyte count,CD4^(+)T lymphocyte count,CD8^(+)T lymphocyte count were lower.The positive rate of novel coronavirus total antibody,IgG antibody and IgM antibody in the imported group were higher than those in the local group(P≤0.05).The negative conversion time of the median nucleic acid was shorter than that of local patients(P≤0.05).Conclusion There are differences in sex ratio,age,complications,clinical manifestations,lymphocyte measurement value,T lymphocyte count and negative conversion time of nucleic acid between overseas imported and local COVID-19 patients in Chengdu.The local patients are mostly elderly and have more complicated conditions,but all of them have good prognosis.