病原体灭活技术在血液成分中的应用进展及质量评价

Advances of pathogen inactivation technology in blood components and quality evaluation

通过献血者筛查、病原体抗原抗体检测、核酸检测的全覆盖,感染性输血风险已降至极低水平,病原体灭活技术(PRT)在保障血液安全方面发挥了不可替代的作用。理想的PRT除了能有效去除血液中的目标病原体外,更重要的是能够最大限度地保持血液中有效成分的活性、不影响被处理血液成分的治疗效果。本文主要对病原体灭活技术的发展进行概述,并讨论了病原体灭活处理对血液成分质量的影响,为改进或开发新的处理技术提供了参考。

Through the screening of blood donors,detection of pathogen antigen and antibody,full coverage of nucleic acid detection,the risk of infectious blood transfusion has been reduced to a very low level.Especially,pathogen inactivation technology(PRT)has played an irreplaceable role in ensuring blood safety.The best way to inactivate pathogens is not only to effectively remove the target pathogens in the blood,but also to maintain the activity of active ingredients in the blood to the maximum extent,and it doesn′t affect the effect of blood therapy.In this paper,the development of pathogen inactivation technology is summarized,and the influence of pathogen inactivation treatment on the quality of blood components is discussed.It provides references for improving or developing new processing technology.