组织工程中细胞与生物材料相互作用研究进展

Interactions between cells and biomaterials in tissue engineering:a review

种子细胞、生物材料和生长因子是组织工程三要素。生物材料模拟体内细胞外基质,为细胞提供良好的生长附着环境,维持细胞的活力和功能。材料表面的理化性质和表面改性分子直接影响细胞的粘附、增殖、迁移和分化等细胞行为,进而影响细胞功能和组织再生效果。材料表面修饰分子是细胞表面粘附和生长的直接接触位置,因此细胞与生物材料表面修饰分子的相互作用是组织工程的关键。文中重点介绍表面修饰分子对细胞表型及功能的影响,为组织工程关键问题的研究提供参考。

Seed cells,biomaterials and growth factors are three important aspects in tissue engineering.Biomaterials mimic extra cellular matrix in vivo,providing a sound environment for cells to grow and attach,so as to maintain cell viability and function.The physicochemical properties and modification molecules of material surface mediate cell behaviors like cell adhesion,proliferation,migration and differentiation,which in turn affect cellular function and tissue regeneration efficacy.Furthermore,the modification molecules of material surface are the direct contact point for cell adhesion and growth.Therefore,the interactions between cells and surface modification molecules are the key to tissue engineering.This review summarizes the effects of surface modification molecules on cell phenotypes and functions.