应变式弹性成像对局部晚期乳腺癌患者新辅助化疗的评估价值

Evaluation value of strain elastography for the patients with locally advanced breast cancer treated with NACT

目的探讨应变式弹性成像对局部晚期乳腺癌患者新辅助化疗(NACT)治疗的评估价值。方法选取2016年6月-2020年6月于该院进行NACT治疗后进行手术的局部晚期乳腺癌患者134例,术后参照病理结果对实体瘤疗效进行评价。将患者分为治疗有效组和治疗无效组。对两组患者进行彩色超声检测和应变式弹性成像检测。对比两组患者的应变式弹性成像参数(弹性评分、应变率比值)和诊断效能(阳性预测值、阴性预测值、灵敏度、特异度及准确度)。结果与治疗无效组相比,治疗有效组弹性评分、应变率比值均有所下降(3.92±1.02 vs.2.05±1.05;2.34±0.65 vs.1.40±0.26,均P<0.05);与常规超声检测手段相比,应变式弹性成像技术阳性预测值、阴性预测值、灵敏度、特异度及准确度均有所上升(96.49%vs.88.46%,96.10%vs.85.36%,94.82%vs.79.31%,97.36%vs.92.10%,96.26%vs.86.56%,均P<0.05)。结论使用应变式弹性成像对局部晚期乳腺癌患者NACT治疗后进行检测,具有较好的灵敏度、特异度及准确性,具有较好的临床诊断价值。

Objective To explore the evaluation value of strain elastography for neoadjuvant chemotherapy(NACT)treatment in patients with locally advanced breast cancer.Methods A total of 134 locally advanced breast cancer patients who underwent surgery after NACT in our hospital from June 2016 to June 2020 were selected,and the curative effect of solid tumors was evaluated by reference to the pathological results after surgery.Patients were divided into a treatment effective group and a treatment ineffective group.Color ultrasound detection as well as strain elastography was performed on both patient groups.Strain elastography parameters[elasticity score,strain rate ratio]as well as diagnostic efficacy[positive predictive value,negative predictive value,sensitivity,specificity,accuracy]were compared between the two groups.Results Compared with the ineffective group,the elasticity score and strain rate ratio of the effective group were decreased(3.92±1.02 vs.2.05±1.05;2.34±0.65 vs.1.40±0.26,allP<0.05);Compared with conventional ultrasound detection methods,the positive predictive value,negative predictive value,sensitivity,specificity and accuracy of strain elastography were all increased(96.49%vs.88.46%,96.10%vs.85.36%,94.82%vs.79.31%,97.36%vs.92.10%,96.26%vs.86.56%,all P<0.05).Conclusion The use of strain elastography to detect tumors after NACT in patients with locally advanced breast cancer has shown excellent sensitivity,specificity,and accuracy,and it has a good clinical diagnostic value.