高压氧联合依达拉奉对老年急性脑梗死患者NIHSS评分及血管新生分子水平的影响

Effect of hyperbaric oxygen with idaravon on NIHSS score and angiogenic molecular levels in elderly patients with acute cerebral infarction

目的高压氧联合依达拉奉对老年急性脑梗死患者NIHSS评分及血管新生分子水平的影响。方法回顾性分析2019年1—12月本院收治的93例老年急性脑梗死患者的临床资料,根据治疗方式的不同分为观察组(高压氧联合依达拉奉及丁苯酞治疗,n=47)和对照组(高压氧联合丁苯酞治疗,n=46),比较两组神经功能指标、血管新生分子指标、国立卫生研究院卒中量表(NIHSS)评分。结果观察组血清胶质纤维酸性蛋白(GFAP)、脑特异性蛋白(S100β)、神经元特异性烯醇化酶(NSE)水平均低于对照组,血管通透因子(VEGF)、血管生成素-2(Ang-2)水平均高于对照组,NIHSS评分低于对照组,差异均有统计学意义(P<0.05)。结论高压氧联合依达拉奉及丁苯酞可有效抑制老年急性脑梗死患者血清GFAP、S100β、NSE水平,改善神经功能,促进血管新生。

Objective The effect of hyperbaric oxygen with idaravon on NIHSS score and angiogenic molecule level in elderly patients with acute cerebral infarction.Methods The clinical data of 93 patients admitted to our hospital with acute cerebral infarction were retrospectively analyzed from January 2019 to December 2019.According to different treatment methods,they were divided into observation group(hyperbaric oxygen combined with edaravone and butylphthalide,n=47)and control group(hyperbaric oxygen combined with butylphthalide,n=46).The nerve function index,angiogenic molecular index and National Institutes of Health stroke scale(NIHSS)score were compared between two groups.Results The levels of serum glial fibrillary acidic protein(GFAP),brain specific protein(S100β)and neuron specific enolase(NSE)in the observation group were lower than those in the control group,the levels of vascular permeability factor(VEGF)and Angiopoietin-2(ANG-2)were higher than those in the control group,and the NIHSS score was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Hyperbaric oxygen combined with idaravon and buphthalein can effectively inhibit serum GFAP,S100 and NSE in elderly patients with acute cerebral infarction,improve neurofunction and promote angiogenesis.