摘要
恶性肿瘤是人类因疾病死亡的主要因素,新型高效低毒的抗肿瘤药物已成为目前社会研究的热点。苝酰亚胺衍生物(perylenediimides derivatives,PDIs)是具有共轭大π键的大分子,荧光效率优异、稳定性高且化学可修饰性强,可作为抗肿瘤药物、药物载体、医用荧光探针等用于肿瘤疾病的诊断和治疗。本文综述了近年来国内外学者对苝酰亚胺衍生物在抗肿瘤作用方面的研究概况,并对其发展做了展望。
Malignant tumor is the main cause of human death due to disease.New anti-tumor drugs with high efficiency and low toxicity have become the focus of social research at present.Perylenediimides derivatives(PDIs)were conjugated largeπ-bond macromolecules with high stability,they have excellent fluorescence efficiency and strong chemical modifiability,which could be used as anti-tumor drugs,drug carriers and medical fluorescent probes for tumor diagnosis and treatment.In this paper,the research on the antitumor effects of perylene imide derivatives is reviewed in recent years,and its development is prospected.
作者
王香颖
罗天姿
李恬
李香莹
付丽娜
Wang Xiangying;Luo Tianzi;Li Tian;Li Xiangying;Fu Lina(School of Midicine,Huanghe Science&Technology College,Zhengzhou 450063,China)
出处
《山东化工》
CAS
2021年第16期91-92,共2页
Shandong Chemical Industry
基金
河南省大学生创新创业训练计划项目(S202011834009)。
关键词
苝酰亚胺衍生物
抗肿瘤
结构修饰
perylenediimide derivatives
antitumor
structural modification