食管胃交界部收缩指数(EGJ-CI)对胃食管反流病患者抗反流屏障功能的判断价值

The Value of Esophagogastric Junction Contraction Index (EGJ-CI) in the Evaluationof Anti-reflux Barrier Function in Patients with Gastroesophageal Reflux Disease

目的:探讨食管胃交界部收缩指数(EGJ-CI)对胃食管反流病患者抗反流屏障功能的判断价值。方法:纳入某院2017年4月~2021年4月收治的58例患者,29例为胃食管反流病,29例为功能性烧心,分别检测两组患者的EFJ-CI、EGJ-CIT、EGJ部静息压力、IRP4s,同时完成食管高分辨压力测定,分析对比两组之间相关参数的差异以及与反流参数的关系。结果:两组患者年龄、性别无显著差异(P>0.05),胃食管反流病组Gerd-Q、DeMeester积分低于功能性烧心组;胃食管反流病组pH<4时间、pH<4时间比例、酸反流次数、弱酸反流次数、非酸反流次数高于功能性烧心组(P<0.05);胃食管反流病组EFJ-CI、EGJ-CIT、EGJ部静息压力均低于功能性烧心组(P<0.05),两组IRP4s无显著差异(P>0.05);EFJ-CI与食管胃酸暴露以及酸反流事件呈现负相关(P<0.05);EGJ-CIT、EGJ部静息压力、IRP4s与食管胃酸暴露以及酸反流事件呈现微弱负相关。结论:EGJ-CI能够有效的反映胃食管反流病患者抗反流屏障功能组的变化,且在胃食管反流病与功能性烧心两种疾病中存在显著差异,在鉴别胃食管反流病与功能性烧心两种疾病具有一定的临床价值。

Objective:To investigate the value of esophagogastric junction contraction index(EGJ-CI)in the evaluation of anti-reflux barrier function in patients with gastroesophageal reflux disease.Methods:A total of 58 patients admitted to a hospital from April 2017 to April 2021 were included,including 29 patients with gastroesophageal reflux disease and 29 patients with functional heartburn.EFJ-CI,EGJ-CIT,EGJ resting pressure and IRP4s of the two groups of patients were detected respectively,and high resolution pressure of the esophagus was measured at the same time.The differences between the two groups of relevant parameters and their relationship with the regurgitation parameters were analyzed and compared.Results:There was no significant difference in age and sex between 2 groups(P>0.05).GERD-Q and Demeester scores in the gastroesophageal reflux disease group were lower than those in the functional heartburn group.The pH<4 time,pH<4 time ratio,acid reflux frequency,weak acid reflux frequency and non-acid reflux frequency in the gastroesophageal reflux disease group were higher than those in the functional heartburn group(P<0.05).EFJ-CI,EGJ-CIT and EGJ resting pressure in the gastroesophageal reflux disease group were all lower than those in the functional heartburn group(P<0.05),and there was no significant difference in IRP4s between the two groups(P>0.05).EFJ-CI was negatively correlated with esophageal and gastric acid exposure and acid reflux events(P<0.05).EGJ-CIT,resting pressure in EGJ and IRP4s were negatively correlated with esophageal and gastric acid exposure and acid reflux events.Conclusion:EGJ-CI can effectively reflect the changes of anti-reflux barrier function group in patients with GERD,and there is a significant difference between GERD and functional heartburn,which has certain clinical value in differentiating GERD and functional heartburn.