阿奇霉素联合地塞米松对小儿支原体感染所致大叶性肺炎患儿血清炎症因子和肺功能的影响

Effects of azithromycin combined with dexamethasone on serum inflammatory factors and pulmonary function in children with lobar pneumonia caused by mycoplasma infection

目的分析阿奇霉素联合地塞米松对小儿支原体感染所致大叶性肺炎患儿血清炎症因子和肺功能的影响。方法回顾性选取本院收治的100例小儿支原体感染所致大叶性肺炎患儿,依据治疗方法将其分为阿奇霉素单独治疗组(单独治疗组,n=50)、阿奇霉素联合地塞米松治疗组(联合治疗组,n=50)。比较两组的临床疗效、血清炎症因子水平、肺功能指标、症状体征消失时间、住院时间。结果联合治疗组的治疗总有效率高于单独治疗组(P<0.05)。治疗后,两组ESR及血清IL-2、IL-6、CRP水平均降低,且联合治疗组低于单独治疗组(P<0.05)。治疗后,两组的PEF、FEV1、FVC均升高,且联合治疗组高于单独治疗组(P<0.05)。联合治疗组的高热消失时间、肺部阴影消失时间、咳嗽消失时间、住院时间均短于单独治疗组(P<0.05)。结论阿奇霉素联合地塞米松能够有效抑制小儿支原体感染所致大叶性肺炎患儿的炎症反应,改善其肺功能。

Objective To analyze the effects of azithromycin combined with dexamethasone on serum inflammatory factors and pulmonary function in children with lobar pneumonia caused by mycoplasma infection.Methods A total of 100 children with lobar pneumonia caused by mycoplasma infection in our hospital were retrospectively selected and divided into azithromycin alone treatment group(single treatment group,n=50)and azithromycin combined with dexamethasone treatment group(combined treatment group,n=50)according to the treatment methods.The clinical efficacy,serum inflammatory factors levels,pulmonary function indexes,disappearance time of symptoms and signs,hospitalization time of the two groups were compared.Results The total effective rate of treatment in the combined treatment group was higher than that in the single treatment group(P<0.05).After treatment,the ESR,levels of serum IL-2,IL-6 and CRP in the two groups decreased,and those in the combined treatment group were lower than the single treatment group(P<0.05).After treatment,PEF,FEV1 and FVC in the two groups increased,and those in the combined treatment group were higher than the single treatment group(P<0.05).The disappearance time of high fever,lung shadow,cough and hospital stay in the combined treatment group were shorter than those in the single treatment group(P<0.05).Conclusion Azithromycin combined with dexamethasone can effectively inhibit the inflammatory response of children with lobar pneumonia caused by mycoplasma infection,and improve their pulmonary function.