心肌“缺血记忆”分子影像学诊断研究进展

Research Progress in Molecular Imaging Diagnosis of Myocardial “Ischemic Memory”

胸痛患者到急诊科就诊是常见现象,但心肌短暂缺血引起的胸痛症状持续时间较短,胸痛患者就诊时症状已经消失或缓解。在胸痛消失后,常规的心脏检查方法一般难以准确诊断曾经发生过的心肌短暂缺血,这将会导致心肌缺血的漏诊。心肌短暂缺血后,心肌细胞血流减少,同时也会在细胞代谢、基因分子、受体等方面产生一定的变化,且这些变化的持续时间比心肌血流变化的持续时间较长,基于以上变化的分子影像学检查能够检测到症状消失后的心肌缺血,这种现象称心肌"缺血记忆"。本文基于"缺血记忆"原理,在细胞代谢、基因分子、受体等方面阐述分子影像学诊断心肌缺血的新进展。

It is a common phenomenon for patients with symptoms of chest pain to visit the emergency department.Because chest pain is usually temporary and the symptoms disappear quickly,conventional electrocardiogram and serological marker detection usually fail to accurately diagnose myocardial ischemia,leading to delayed or missed diagnosis of ischemia.Myocardial ischemia can cause changes in cells,genetic molecules and receptors.These changes not only occur during ischemia but also persist after the ischemia disappears.Based on these changes,imaging can detect myocardial deficiency after chest pain disappears.This method is usually called"ischemic memory"imaging.Based on the imaging principle of"ischemic memory"and the latest research results at home and abroad,this article describes and reviews the new development of molecular imaging on myocardial"ischemic memory".