氯吡格雷联合阿司匹林双重抗血小板治疗急性脑梗死患者的疗效探讨

The Effect of Clopidogrel Combined with Aspirin on Dual Antiplatelet Therapy in Patients with Acute Cerebral Infarction

目的探究氯吡格雷联合阿司匹林双重抗血小板治疗急性脑梗死患者的临床效果。方法随机选择该院2017年12月—2019年12月期间收治的68例急性脑梗死患者,采用数字单双号模式将该组患者分为两组,包括对照组(单用阿司匹林)与观察组(阿司匹林联合氯吡格雷),各34例。对比分析血液流变学指标、神经功能缺损评分(NIHSS)、日常生活能力评分(ADL)、临床疗效、不良反应情况。结果两组在治疗前的全血低切黏度、血浆黏度、纤维蛋白原、神经功能缺损与日常生活能力对比差异无统计学意义(P>0.05);治疗后,观察组血液流变学指标、NIHSS、ADL优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为91.18%(31/34),高于对照组的67.65%(23/34),差异有统计学意义(χ^(2)=5.757,P<0.05)。对照组不良反应发生率为17.65%(6/34),观察组为20.59%(7/34),差异无统计学意义(χ^(2)=0.095,P>0.05)。结论针对急性脑梗死患者而言,相较于阿司匹林抗血小板治疗方案,氯吡格雷联合阿司匹林双重抗血小板治疗方案的临床疗效更为显著,且血液流变学指标、NIHSS、ADL改善情况更为理想,患者预后情况更为理想。

Objective To explore the clinical effect of clopidogrel combined with aspirin dual antiplatelet therapy in patients with acute cerebral infarction.Methods A random selection of 68 patients with acute cerebral infarction admitted to the Hospital from December 2017 to December 2019.The patients in this group were divided into two groups using the digital single and double number model,including the control group(aspirin alone)and observation group(aspirin combined with clopidogrel),each with 34 cases.Comparative analysis of hemorheology indicators,neurological deficit score(NIHSS),ability of daily living(ADL),clinical efficacy,and adverse reactions.Results There were no statistically significant differences between the two groups of whole blood low-shear viscosity,plasma viscosity,fibrinogen,neurological deficits,and activities of daily living before treatment(P>0.05);after treatment,the observation group's blood rheology indexes,NIHSS and ADL score were better than those of the control group.the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 91.18%(31/34),which was higher than the control group’s 67.65%(23/34),the difference was statistically significant(χ^(2)=5.757,P<0.05).The incidence of adverse reactions in the control group was 17.65%(6/34),and the observation group was 20.59%(7/34).There was no statistically significant difference between the two groups(χ^(2)=0.095,P>0.05).Conclusion For patients with acute cerebral infarction,compared with aspirin antiplatelet therapy,the clinical efficacy of clopidogrel combined with aspirin dual antiplatelet therapy is more significant,and the hemorheology index,NIHSS,and the improvement of the ability of ADL score is more ideal,and the patient's prognosis is more ideal.